TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and interferon (IFN) signaling, through selective autophagy, specifically mitophagy and xenophagy, to energy homeostasis. Thus, it is not surprising that TBK1 is involved in many cellular signaling pathways that contribute to diverse pathologies. In this review the role of TBK1 in autophagic signaling, especially mitophagy and xenophagy, and its contribution to oncogenesis or neurodegenerative diseases will be discussed.

中文翻译：

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TBK1（TANK结合激酶1）介导的健康和疾病自噬调节

TANK 结合激酶 1 (TBK1) 是一种可成药的多功能激酶，在细胞中发挥广泛的功能。这些范围从先天免疫、炎症和干扰素 (IFN) 信号传导，到选择性自噬，特别是线粒体自噬和异体自噬，再到能量稳态。因此，TBK1 参与许多导致不同病理的细胞信号通路也就不足为奇了。在这篇综述中，将讨论 TBK1 在自噬信号传导中的作用，尤其是线粒体自噬和异体自噬，以及它对肿瘤发生或神经退行性疾病的贡献。