Small peptides are handled in the field of sports drug testing analysis as a separate group doping substances. It is a diverse group, which includes but is not limited to growth hormone releasing-factors and gonadotropin-releasing hormone analogues. Significant progress has been achieved during the past decade in the doping control analysis of these peptides. In this article, achievements in the application of liquid chromatography-mass spectrometry-based methodologies are reviewed. To meet the augmenting demands for analyzing an increasing number of samples for the presence of an increasing number of prohibited small peptides, testing methods have been drastically simplified, whilst their performance level remained constant. High-resolution mass spectrometers have been installed in routine laboratories and became the preferred detection technique. The discovery and implementation of metabolites/catabolites in testing methods led to extended detection windows of some peptides, thus, contributed to more efficient testing in the anti-doping community.

小肽在运动药物测试分析领域中作为单独的组掺杂物质进行处理。它是一个多样化的群体，包括但不限于生长激素释放因子和促性腺激素释放激素类似物。在过去的十年中，在这些肽的掺杂控制分析中已经取得了重大进展。本文综述了液相色谱-质谱联用技术的应用进展。为了满足对越来越多的样品分析中是否存在越来越多的禁用小肽的需求，测试方法已大大简化，而其性能水平却保持不变。高分辨率质谱仪已安装在常规实验室中，并成为首选的检测技术。