This study investigated a practical, inexpensive, and effective vibriosis control experimentally for serious causes of severe mortalities of cultured European sea bass (Dicentrarchus labrax) using FKC bacterins of Listonella anguillarum or Vibrio alginolyticus, their cross-protection against L. anguillarum or V. alginolyticus, and their most suitable administration route in D. labrax. The results of L. anguillarum or V. alginolyticus that naturally infected D. labrax during the summer season revealed mass mortalities, hemorrhagic ulceration on different body areas, eye opacity, and many internal pathological lesions. The two pathogens were identified by traditional methods and MALDI-TOF-MS. The gills were recorded with the highest incidence of the two bacteria. Experimental results indicated the superiority of V. alginolyticus FKC bacterin in protection against V. alginolyticus and cross-protection against L. anguillarum. Intraperitoneal injection recorded better immunization results than prolonged immersion for 2 h and dipped immersion for 1 min. In conclusion, intraperitoneal injection of V. alginolyticus FKC bacterin could induce protection against V. alginolyticus and cross-protection against L. anguillarum in D. labrax that could be a valuable means for vibriosis control.

这项研究调查了实用，价廉，有效的控制弧菌为实验培养欧洲鲈鱼（重症死亡的严重的会导致粗养使用的FKC菌苗）鳗利斯顿或溶藻弧菌，反对L.其交叉保护鳗或溶藻弧菌，以及它们在D. labrax中最合适的给药途径。自然感染D. labrax的安哥拉乳杆菌或溶藻弧菌的结果夏季期间，发现大量死亡，不同身体部位的出血性溃疡，眼睛混浊和许多内部病理病变。通过传统方法和MALDI-TOF-MS鉴定了两种病原体。recorded被记录为两种细菌的​​最高发生率。实验结果表明，溶藻弧菌FKC菌素在抗溶藻弧菌和交叉保护鳗藻方面具有优势。腹膜内注射记录的免疫效果优于长时间浸泡2 h和浸泡1 min。总之，腹膜内注射溶藻弧菌FKC细菌素可诱导对溶藻弧菌的保护反对交叉保护L.鳗在D.鲈，可能是弧菌病控制一个有价值的手段。