Abstract

Several fundamentally different pathways may exist to restore a lost structure in closely related species or within the same species of multicellular animals; this phenomenon is described using the example of the echinoderm digestive system. We propose to call this phenomenon “variability of regeneration mechanisms.” In echinoderms, it is manifested as differences in the spatial organization of the regeneration process and in the cell sources that are involved. The variability of regeneration mechanisms in the phylum Echinodermata can probably be explained by the availability of several regeneration pathways in the ancestral forms of deuterostomes, which differ in the involvement of various cell types, the depth of reprogramming of their genome (dedifferentiation or transdifferentiation), and the role of epithelial–mesenchymal transition.

中文翻译：

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棘皮动物的再生机制的变异性。

摘要

在密切相关的物种或同一物种的多细胞动物中，可能存在几种根本不同的途径来恢复丢失的结构。以棘皮动物消化系统为例来描述这种现象。我们建议将此现象称为“再生机制的变异性”。在棘皮动物中，其表现为再生过程的空间组织和所涉及的细胞来源方面的差异。棘皮动物门中再生机制的差异可能可以通过氘代祖先祖先形式中的几种再生途径的可用性来解释，这些途径在各种细胞类型的参与，基因组重编程的深度（去分化或转分化）方面有所不同，以及上皮-间质转化的作用。