Chemical investigation of demosponge Hyrtios erectus (family Thorectidae) resulted in the identification of two scalarane-type sesterterpenes, erectascalaranes A–B, which were characterized as 3-((but-3⁵-enyloxy)methyl)-icosahydro-11-hydroxy-4,4,8,10,13-pentamethyl-20-oxochryseno[2,1-c]furan-12-yl acetate (erectascalarane A) and 3-((but-3⁵-enyloxy)methyl)-hexadecahydro-11-hydroxy-4,4,8,10,13-pentamethylchryseno[2,1-c]furan-20(5bH)-one (erectascalarane B) using detailed spectroscopic experiments. Erectascalarane A exhibited significantly greater attenuation property against pro-inflammatory cyclooxygenase-2 (IC₅₀ 0.80 mM) than that displayed by erectascalarane B (IC₅₀ ~ 1 mM). Erectascalarane A was found to be a potential inhibitor against 5-lipoxygenase (IC₅₀ 1.21 mM), and its activity was significantly higher than that displayed by standard anti-inflammatory agent ibuprofen (IC₅₀ 4.50 mM, p < 0.05). Greater anti-inflammatory selectivity index of erectascalarane A (1.15) than ibuprofen (0.43) also accounted for greater selectivity of the former against cyclooxygenase-2. Erectascalarane A also exhibited significantly greater antioxidant activities against oxidants (IC₅₀ ~ 0.8 mM) than the standard α-tocopherol (IC₅₀ > 1.5 mM). Lesser docking parameters obtained for erectascalarane A at the active site of COX-2 and greater electronic factors acquired from structure–activity analyses (topological polar surface area 82.06) were also in agreement with greater anti-inflammatory activity. Lesser steric bulk and greater electronic properties combined with lower binding energy with cyclooxygenase-2 further reinforced the significant anti-inflammatory potential of erectascalarane A.

对直立假单胞菌（直立科）的化学研究导致鉴定出了两个标量为标量的斯卡拉塔林酯类，即直立标碳烯酮A–B，其特征是3-（（but-3 ⁵ -enyloxy）methyl）-icosahydro-11-hydroxy- 4,4,8,10,13-五甲基-20-氧杂ry啶酮[2,1-c]呋喃-12-乙酸乙酸酯（直立scalarane A）和3-（（but-3 ⁵ -enyloxy）methyl）-hexadecahydro-11 -羟基-4,4,8,10,13-五甲基甲基s [2,1-c]呋喃-20（5bH）-一（直立scalarane B）使用详细的光谱实验。Escalascalarane A对促炎性环氧合酶2（IC ₅₀ 0.80 mM）的抑制作用比Escalascalarane B（IC ₅₀ 〜1 mM）。发现Escalascalarane A是潜在的5-脂氧合酶抑制剂（IC ₅₀ 1.21 mM），其活性显着高于标准抗炎药布洛芬（IC ₅₀ 4.50 mM，p  <0.05）。比起布洛芬（0.43），艾卡塔拉烷烃A（1.15）的抗炎选择性更高，这也说明前者对环氧合酶-2的选择性更高。Erectascalarane A还对氧化剂（IC表现出更大的显著抗氧化活性₅₀  〜0.8毫米）比标准的α生育酚（IC ₅₀ > 1.5 mM）。在COX-2的活性位点获得的对二十碳烷烃A的对接参数较小，并且通过结构活性分析（拓扑极性表面积82.06）获得的更大的电子因子也与更大的抗炎活性相一致。较小的空间体积和较高的电子性能，以及与环氧合酶2的较低结合能，进一步增强了戊四碳六烷A的显着抗炎潜力。