Abstract

This study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10 936 599, TERC rs2 293 607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (OR_c = 3.250, 95% CI = 1.176–8.980, p_c = 0.023; OR_c = 3.09, 95% CI = 1.238–7.717, p_c = 0.016; OR = 0.638, 95% CI = 0.416–0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.

中文翻译：

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MYNN，TERT和TERC基因多态性与土耳其人群前列腺癌的相关性

摘要

这项研究旨在确定在土耳其人群中前列腺癌的发展与MYNN rs10 936 599，TERC rs2 293 607和hTERT MNS16A多态性之间是否存在任何关系。这项研究由77位前列腺癌患者和116位无癌症史的健康患者组成。使用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）方法进行基因分型分析。使用卡方检验和无条件逻辑回归分析评估获得的结果。在研究中，发现患者和对照组之间TERC rs2293607多态性的GG基因型，TERT MNS16A多态性的VNTR-243 / 243基因型和等位基因243具有统计学意义（OR _c = 3.250，95％CI = 1.176 –8.980，p_c = 0.023；或_c = 3.09，95％CI = 1.238-7.717，p _c = 0.016；OR = 0.638，95％CI = 0.416-0.978，p = 0.038）。另一方面，土耳其人群中MYNN rs109365999多态性与前列腺癌之间没有显着相关性。总之，获得的数据表明，TERC rs2293607和TERT MNS16A VNTR-243 / 243多态性可能是土耳其人群前列腺癌发展的潜在危险因素，并可能被建议作为预后指标。