Odor perception begins with the detection of odorant molecules by the main olfactory epithelium located in the nasal cavity. Odorant molecules bind to and activate a large family of G-protein-coupled odorant receptors and trigger a cAMP-mediated transduction cascade that converts the chemical stimulus into an electrical signal transmitted to the brain. Morever, odorant receptors and cAMP signaling plays a relevant role in olfactory sensory neuron development and axonal targeting to the olfactory bulb. This review will first explore the physiological response of olfactory sensory neurons to odorants and then analyze the different components of cAMP signaling and their different roles in odorant detection and olfactory sensory neuron development.

中文翻译：

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啮齿动物主要嗅觉系统中的环 AMP 信号通路

气味感知始于位于鼻腔中的主要嗅觉上皮对气味分子的检测。气味分子结合并激活一大类 G 蛋白偶联气味受体，并触发 cAMP 介导的转导级联反应，将化学刺激转化为传输到大脑的电信号。此外，气味受体和 cAMP 信号在嗅觉感觉神经元发育和轴突靶向嗅球中起着相关作用。本综述将首先探讨嗅觉神经元对气味的生理反应，然后分析 cAMP 信号的不同成分及其在气味检测和嗅觉神经元发育中的不同作用。