Since the discovery of liposomes, this technology has been evolving from the studying of biological membranes to various multidisciplinary studies, especially cosmeceuticals and pharmaceuticals. However, the conventional liposomes encountered many challenges such as metabolite by the process of phagocytosis, instability in plasma, and short half-life. In this study, we synthesized 41 kDa N-stearoyl chitosan to be used as a stealth coating materials for soy lecithin liposomes. Soy lecithin liposomes were prepared using the thin-film hydration technique and coated with N-stearoyl chitosan, which reduced the average particle size of liposomes down to 36% and zeta potential to −15.2 mV. The morphology of liposomes was further confirmed to be spherical in shape by using the optical polarizing microscope. More than 90% of itraconazole (ITZ) was successfully encapsulated, while the in vitro release studies showed a significantly slower release of ITZ from N-stearoyl chitosan-coated soy lecithin liposomes as compared to free ITZ. These indicated that N-stearoyl chitosan could possibly be a good coating material for soy lecithin liposomes carrying various antifungal and antiviral drugs.

自从发现脂质体以来，这项技术已经从生物膜的研究发展到各种多学科研究，尤其是药妆和药物。然而，常规脂质体遇到了许多挑战，例如吞噬作用过程中的代谢产物，血浆中的不稳定以及半衰期短。在这项研究中，我们合成了41 kDa N-硬脂酰壳聚糖，用作大豆卵磷脂脂质体的隐形涂层材料。使用薄膜水化技术制备大豆卵磷脂脂质体并用N包被-硬脂酰壳聚糖，将脂质体的平均粒径降低至36％，ζ电位降低至-15.2 mV。通过使用光学偏光显微镜进一步确认脂质体的形态为球形。伊曲康唑（ITZ）的90％以上的被成功地包封，而在体外释放的研究显示ITZ的从显著较慢的释放Ñ -stearoyl壳聚糖包被的大豆卵磷脂的脂质体相比，自由ITZ。这些表明N-硬脂酰壳聚糖可能是携带各种抗真菌和抗病毒药物的大豆卵磷脂脂质体的良好包衣材料。