Abstract

Transition metal ions are essential micronutrients for all living organisms and exert a wide range of effects on human health. The uptake of transition metal ions occurs primarily in the gastrointestinal tract, which is colonized by trillions of bacterial cells. In recent years, increasing studies have indicated that transition metals have regulatory effects on the gut microbiota. In view of the significant effect of the gut microbiota on human health and involvement in the pathogenesis of a wide range of diseases, in this paper, we provide a comprehensive discussion on the regulatory effects of four kinds of transition metal ions on the gut microbiota. A total of 20 animal model and human studies concerning the regulatory effects of four types of transition metal ions (i.e., iron, copper, zinc, and manganese) on gut microbiota were summarized. Both the deficiency and supplementation of these transition metal ions on the gut microbiota were considered. Furthermore, the potential mechanisms governing the regulatory effects of transition metal ions on the gut microbiota were also discussed.

Key points

• Regulatory effects of iron, copper, zinc, and manganese on gut microbiota were reviewed.

• Both deficiency and supplementation of metal ions on gut microbiota were considered.

• Mechanisms governing effects of metal ions on gut microbiota were discussed.

中文翻译：

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过渡金属补充/缺乏对肠道菌群的调节作用

摘要

过渡金属离子是所有活生物体必不可少的微量营养素，对人体健康具有广泛的影响。过渡金属离子的吸收主要发生在胃肠道中，胃肠道被数万亿细菌细胞定居。近年来，越来越多的研究表明过渡金属对肠道菌群具有调节作用。鉴于肠道菌群对人类健康的显着影响以及涉及多种疾病的发病机理，在本文中，我们对四种过渡金属离子对肠道菌群的调节作用进行了全面的讨论。总结了20种动物模型和人体研究，它们涉及四种类型的过渡金属离子（铁，铜，锌和锰）对肠道菌群的调节作用。这些过渡金属离子在肠道菌群上的缺乏和补充都被考虑了。此外，还讨论了控制过渡金属离子对肠道菌群的调节作用的潜在机制。

关键点

•审查了铁，铜，锌和锰对肠道菌群的调节作用。

•同时考虑了肠道菌群缺乏和补充金属离子。

•讨论了控制金属离子对肠道菌群影响的机制。