Triple-negative breast cancer(TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of Epithelial-mesenchymal transition(EMT). Recent studies have shown that long non-coding RNA(LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT related signal pathways of TNBC metastasis. We also discussed the clinical research, application and challenges of LncRNA in TNBC.

中文翻译：

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EMT相关lncRNA在三阴性乳腺癌转移过程中的作用

三阴性乳腺癌(TNBC)是乳腺癌中恶性程度最高、致死率最高的亚型，其特征是ER、PR和HER2的阴性表达。转移是影响TNBC预后的主要因素，转移过程与上皮间质转化（EMT）异常激活有关。最近的研究表明，长链非编码RNA（LncRNA）在调节TNBC的转移和侵袭中起重要作用。因此，基于转移相关的EMT信号通路，大量研究证实了LncRNA参与了TNBC转移的分子机制，这将为改善TNBC的治疗和预后提供新的策略。在这篇综述中，我们总结了许多与转移过程中涉及的 EMT 相关的信号通路。lncRNAs在TNBC转移的EMT相关信号通路中的最新研究进展。我们还讨论了 LncRNA 在 TNBC 中的临床研究、应用和挑战。