Photochemical synthesis of 3-hydroxyphenanthro[9,10-c]furan-1(3H)-ones from α-keto acids and alkynes,Organic Chemistry Frontiers

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Photochemical synthesis of 3-hydroxyphenanthro[9,10-c]furan-1(3H)-ones from α-keto acids and alkynes
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-1-4 , DOI: 10.1039/d0qo01487g
Beibei Zhao _{1,

2,

3,

4,

5} , Zhen Zhang _{1,

2,

3,

4,

5} , Yu Ge _{1,

2,

3,

4,

5} , Pinhua Li _{1,

2,

3,

4,

5} , Tao Miao _{1,

2,

3,

4,

5} , Lei Wang _{1,

2,

3,

4,

5}

Affiliation

A novel and efficient method for the synthesis of 3-hydroxyphenanthro[9,10-c]furan-1(3H)-ones has been achieved from readily available α-keto acids and alkynes through photo-initiated transformation, providing a range of structurally diverse products in good to excellent yields under mild conditions. Mechanistic studies reveal that this reaction undergoes photo-induced radical addition/cyclization and hydrogen evolution cascade processes.

中文翻译：

由α-酮酸和炔烃光化学合成3-羟基菲咯啉[9,10-c]呋喃-1（3H）-一

通过光引发的转化，从容易获得的α-酮酸和炔烃中获得了一种新颖且有效的合成3-羟基菲[9,10- c ]呋喃-1（3 H）-的方法，提供了一系列在温和的条件下，结构多样的产品，收率好至极好。机理研究表明，该反应经历了光诱导的自由基加成/环化和氢释放级联过程。

更新日期：2021-01-14

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