Background Fibulin-5 and ischemia-modified albumin (IMA) levels increase in acute phase of cerebrovascular diseases, yet data regarding their levels in various stroke subtypes and correlation with severity and prognosis are still insufficient. This work aims to evaluate serum IMA and fibulin-5 as markers for early detection and predicting prognosis in acute cerebrovascular disease. Method This case-control study was done on 100 patients with first time stroke, assessed by the National Institute of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) within the first 24 h after stroke event, lesion volume was calculated, serum fibulin-5 and IMA levels were measured in the first few hours of stroke, and their levels were compared with levels measured in 75 control subjects. Three months later, stroke patients were assessed by the modified Rankin Scale (MRS). Results Fibulin-5 and IMA were significantly higher in the patient than in the control group and were positively correlated with lesion volume and NIHSS score but inversely correlated with GCS score. Fibulin-5 was statistically higher in hemorrhage group, whereas IMA was statistically higher in infarction group. MRS score was positively correlated with fibulin-5 levels at onset of stroke but not with IMA. Conclusion Fibulin-5 and ischemia-modified albumin are increased during the acute stroke phase and correlated with severity of stroke, but only fibulin-5 shows significant correlation with prognosis.

中文翻译：

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缺血修饰白蛋白和 fibulin-5 作为急性脑血管病的诊断和预后标志物

背景 脑血管疾病急性期 Fibulin-5 和缺血修饰白蛋白 (IMA) 水平升高，但关于其在各种卒中亚型中的水平以及与严重程度和预后的相关性的数据仍然不足。本工作旨在评估血清 IMA 和 fibulin-5 作为早期检测和预测急性脑血管疾病预后的标志物。方法 本病例对照研究对 100 例首次脑卒中患者，在脑卒中后 24 h 内采用美国国立卫生研究院卒中量表（NIHSS）和格拉斯哥昏迷量表（GCS）进行评估，计算病灶体积、血清fibulin-5 和 IMA 水平在中风的最初几个小时内被测量，并将它们的水平与 75 名对照受试者的水平进行比较。三个月后，卒中患者采用改良的 Rankin 量表 (MRS) 进行评估。结果患者Fibulin-5、IMA显着高于对照组，与病灶体积、NIHSS评分呈正相关，与GCS评分呈负相关。Fibulin-5在出血组有统计学意义，而IMA在梗死组有统计学意义。MRS 评分与卒中发作时的 fibulin-5 水平呈正相关，但与 IMA 无关。结论 脑卒中急性期Fibulin-5和缺血修饰白蛋白升高，与脑卒中严重程度相关，但仅fibulin-5与预后显着相关。结果患者Fibulin-5、IMA显着高于对照组，与病灶体积、NIHSS评分呈正相关，与GCS评分呈负相关。Fibulin-5在出血组有统计学意义，而IMA在梗死组有统计学意义。MRS 评分与卒中发作时的 fibulin-5 水平呈正相关，但与 IMA 无关。结论 脑卒中急性期Fibulin-5和缺血修饰白蛋白升高，与脑卒中严重程度相关，但仅fibulin-5与预后显着相关。结果患者Fibulin-5、IMA显着高于对照组，与病灶体积、NIHSS评分呈正相关，与GCS评分呈负相关。Fibulin-5在出血组有统计学意义，而IMA在梗死组有统计学意义。MRS 评分与卒中发作时的 fibulin-5 水平呈正相关，但与 IMA 无关。结论 脑卒中急性期Fibulin-5和缺血修饰白蛋白升高，与脑卒中严重程度相关，但仅fibulin-5与预后显着相关。