Non-genetic cell-surface modification with a self-assembling molecular glue,Chemical Communications

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Non-genetic cell-surface modification with a self-assembling molecular glue
Chemical Communications ( IF 4.3 ) Pub Date : 2021-1-5 , DOI: 10.1039/d0cc07171d
Hayase Hakariya _{1,

2,

3,

4,

5} , Ippei Takashima _{1,

2,

3,

4} , Misao Takemoto _{1,

2,

3,

4} , Naotaka Noda _{1,

2,

3,

4,

5} , Shin-ichi Sato _{1,

2,

3,

4} , Motonari Uesugi _{1,

2,

3,

4,

6}

Affiliation

This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.

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