In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies. Owing to its numerous potential applications, in the past two decades, there is an increase in the importance of designing novel quinazolines, exploring promising routes to synthesize quinazolines, investigating different properties of quinazolines, and seeking for potential applications of quinazolines. The present review article describes synthesis of quinazolines via eco-friendly, mild, atom-efficient, multi-component synthetic strategies reported in the literature. The discussion is divided into different parts as per the key methods involved in the formation of quinazoline skeletons, aiming to provide readers an effective methodology to a better understanding. Consideration has been taken to cover the most recent references. Expectedly, the review will be advantageous in future research for synthesizing quinazolines and developing more promising synthetic approaches.

在药物化学中，最重要的杂环化合物之一是喹唑啉，它们具有广泛的生物学特性，例如抗菌，抗真菌，抗HIV，抗癌，抗炎和止痛功效。由于其潜在的广泛应用，在过去的二十年中，设计新颖的喹唑啉，探索合成喹唑啉的有前途的途径，研究喹唑啉的不同性质以及寻求喹唑啉的潜在应用的重要性日益增加。本综述文章描述了喹唑啉的合成通过文献报道了环保，温和，原子效率高，多组分的合成策略。根据形成喹唑啉骨架的关键方法，讨论分为不同部分，旨在为读者提供一种更好地理解的有效方法。已考虑涵盖最新的参考文献。预期，该综述对于合成喹唑啉和开发更有前景的合成方法的未来研究将是有利的。