The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental and neurological symptoms. For that we conducted a comprehensive systematic literature review of four online databases, including Web of Science, PubMed, Scopus and Embase. All relevant articles that reported psychiatric/psychological symptoms or disorders in COVID-19 without considering time and language restrictions were assessed. All the study procedures were performed based on the PRISMA criteria. Due to the screening, 14 studies were included. The current study result indicated that, the pooled prevalence of CNS or mental associated disorders with 95% CI was 50.68% (6.68–93.88). The most prevalence symptoms were hyposmia/anosmia/olfactory dysfunction (number of study: 10) with 36.20% (14.99–60.51). Only one study reported numbness/paresthesia and dysphonia. Pooled prevalence of numbness/paresthesia and dysphonia was 5.83% (2.17–12.25) and 2.39% (10.75–14.22). The pooled prevalence of depression and anxiety was 3.52% (2.62–4.54) and 13.92% (9.44–19.08). Our findings demonstrate that COVID-19 has a certain relation with neurological symptoms. The hypsomia, anosmia or olfactory dysfunction was most frequent symptom. Other symptoms were headache or dizziness, dysgeusia or ageusia, dysphonia and fatigue. Depression, anxiety, and confusion were less frequent symptoms.

中文翻译：

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COVID-19相关中枢神经系统表现，精神和神经症状：系统评价和荟萃分析

持续不断的2019年冠状病毒疾病大流行（COVID-19）已在全球感染了超过2700万例确诊病例，并有890万例死亡。病毒感染的真实性可以感染神经系统。这些病毒感染可表现出广泛的表现形式。本研究的目的是系统地审查与COVID-19相关的中枢神经系统表现，精神和神经症状。为此，我们对四个在线数据库进行了全面的系统文献综述，其中包括Web of Science，PubMed，Scopus和Embase。评估了所有报告COVID-19中的精神/心理症状或疾病而未考虑时间和语言限制的相关文章。所有研究程序均基于PRISMA标准进行。由于筛选，包括了14项研究。当前的研究结果表明，合并有95％CI的CNS或精神相关障碍的患病率为50.68％（6.68–93.88）。患病率最高的症状是低渗/失眠/嗅觉功能障碍（研究数量：10），占36.20％（14.99-60.51）。只有一项研究报道了麻木/感觉异常和声音障碍。麻木/感觉异常和发声障碍的合并患病率为5.83％（2.17–12.25）和2.39％（10.75–14.22）。抑郁和焦虑的合并患病率分别为3.52％（2.62-4.54）和13.92％（9.44-19.08）。我们的发现表明，COVID-19与神经系统症状有一定关系。催眠，失眠或嗅觉功能障碍是最常见的症状。其他症状是头痛或头晕，消化不良或老龄化，发声困难和疲劳。抑郁，焦虑和困惑是较不常见的症状。