The alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spectrum agents with a high potential as novel therapeutics. In this context, antimicrobial peptides, cell penetrating peptides, and antiviral peptides play a major role, and have been suggested as promising solutions. Furthermore, dendrimers are to be considered as suitable macromolecules for the development of advanced nanosystems that are able to complement the typical properties of dendrimers with those of peptides. This review focuses on the description of nanoplatforms constructed with peptides and dendrimers, and their applications.

中文翻译：

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肽和树枝状大分子：如何对抗病毒和细菌感染


抗菌素耐药性的惊人增长和最近的病毒大流行事件增加了对通过创新药物采取新方法的需求，这些创新药物主要能够附着在细菌和病毒的外层，造成永久性损害。抗菌分子是有效的广谱药物，具有作为新型疗法的巨大潜力。在这种情况下，抗菌肽、细胞穿透肽和抗病毒肽发挥着重要作用，并被认为是有前途的解决方案。此外，树枝状聚合物被认为是适合开发先进纳米系统的大分子，该纳米系统能够用肽的特性补充树枝状聚合物的典型特性。本综述重点介绍用肽和树枝状聚合物构建的纳米平台及其应用。