Abstract

A series of compounds, in which a novel 6-(4-aminophenyl)pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives were synthesized and tested for their antimicrobial and antifungal activities. Among all synthesized compounds, compound 7a showed remarkable antimicrobial activity with overall target micro-organisms and compounds 7g and 7l displayed significant inhibitory activity against Escherichia coli (Ec) and Scedosporium (Sc) respectively.

中文翻译：

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新型吡咯并[1,2-d] [1,2,4]三嗪-1（2H）-一衍生物的合成及生物活性

摘要

合成了一系列新型6-（4-氨基苯基）吡咯并[1,2-d] [1,2,4] triazin-1（2H）-one衍生物的化合物，并测试了其抗菌和抗真菌活性。在所有合成的化合物中，化合物7a对总体目标微生物均表现出显着的抗菌活性，化合物7g和7l分别对大肠杆菌（Ec）和Scedosporium（Sc）表现出显着的抑制活性。