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Synthesis and biological activities of novel pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives
Synthetic Communications ( IF 1.8 ) Pub Date : 2021-01-14 Jesurajan Jebamani, Shubha Pranesh, Jayadev Shivalingappa, Manjunatha Narayanarao, Mussuvir Pasha
中文翻译:
新型吡咯并[1,2-d] [1,2,4]三嗪-1(2H)-一衍生物的合成及生物活性
更新日期:2021-01-14
Synthetic Communications ( IF 1.8 ) Pub Date : 2021-01-14 Jesurajan Jebamani, Shubha Pranesh, Jayadev Shivalingappa, Manjunatha Narayanarao, Mussuvir Pasha
Abstract
A series of compounds, in which a novel 6-(4-aminophenyl)pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives were synthesized and tested for their antimicrobial and antifungal activities. Among all synthesized compounds, compound 7a showed remarkable antimicrobial activity with overall target micro-organisms and compounds 7g and 7l displayed significant inhibitory activity against Escherichia coli (Ec) and Scedosporium (Sc) respectively.
中文翻译:
新型吡咯并[1,2-d] [1,2,4]三嗪-1(2H)-一衍生物的合成及生物活性
摘要
合成了一系列新型6-(4-氨基苯基)吡咯并[1,2-d] [1,2,4] triazin-1(2H)-one衍生物的化合物,并测试了其抗菌和抗真菌活性。在所有合成的化合物中,化合物7a对总体目标微生物均表现出显着的抗菌活性,化合物7g和7l分别对大肠杆菌(Ec)和Scedosporium(Sc)表现出显着的抑制活性。