Abstract

1. Triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) are prominent explosive threats. Mitigation of peroxide explosives is a priority among the law enforcement community, with canine (K9) units being trained to recognize the scent of peroxide explosives. Herein, the metabolism, blood distribution and toxicity of peroxide explosives is investigated.

2. HMTD metabolism studies in liver microsomes identified two potential metabolites, tetramethylene diperoxide diamine alcohol aldehyde (TMDDAA) and tetramethylene peroxide diamine dialcohol dialdehyde (TMPDDD).

3. Blood stability studies in dogs and humans showed that HMTD was rapidly degraded, whereas TATP remained for at least one week.

4. Toxicity studies in dog and human hepatocytes indicated minimum cell death for both TATP and HMTD.

摘要

1. 三丙酮三过氧化物（TATP）和六亚甲基三氧化二胺（HMTD）是主要的爆炸威胁。减轻过氧化物炸药是执法界的优先考虑事项，对犬科（K9）进行了培训以认识到过氧化物炸药的气味。在此，研究了过氧化物炸药的代谢，血液分布和毒性。

2. 肝微粒体中的HMTD代谢研究确定了两种潜在的代谢产物，即四亚甲基二过氧化物二胺醇醛（TMDDAA）和四亚甲基过氧化二胺二乙醇二醛（TMPDDD）。

3. 对狗和人的血液稳定性研究表明，HMTD迅速降解，而TATP保留了至少一周。

4. 在狗和人肝细胞中的毒性研究表明，对于TATP和HMTD而言，其细胞死亡最小。