The reaction of 19-phenoxybilinones with Zn²⁺ caused ring-closure to afford the 5-oxaporphyrin zinc complex under ambient conditions. While bilinones are non-fluorescent, the 5-oxaporphyrin zinc complex fluoresced red light. 19-Phenoxybilinone can be employed as a fluorogenic zinc ion sensor. Among various metal ions, only Zn²⁺, Cu²⁺ and Co²⁺ can induce the ring closure reaction to yield 5-oxaporphyrin metal complexes, and only the zinc complex was fluorescent. Submicromolar Zn²⁺ can be detected by 19-phenoxybilinone both in organic solvents and aqueous solvents.

中文翻译：

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Zn2 +和Cu2 +诱导的19个取代胆甾酮与5-氧杂卟啉金属配合物的闭环反应–在开启红色荧光锌离子探针上的应用–

19-苯氧基胆甾酮与Zn ²⁺的反应在环境条件下引起闭环，得到5-氧杂卟啉锌配合物。胆甾醇不发荧光，而5-氧杂卟啉锌配合物发出红色荧光。19-苯氧基比林酮可以用作荧光锌离子传感器。在各种金属离子中，只有Zn 2 ⁺，Cu ²⁺和Co ²⁺可以引起闭环反应，生成5-氧杂卟啉金属配合物，只有锌配合物具有荧光性。在有机溶剂和水性溶剂中，亚微摩尔Zn ²⁺均可通过19-苯氧基胆碱测定。