Regioselective Synthesis of 2,3‐Dihydrobenzo[f]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction,Advanced Synthesis & Catalysis

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Regioselective Synthesis of 2,3‐Dihydrobenzo[f]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-13 , DOI: 10.1002/adsc.202001255
Ying‐Chun He ₁ , Yan‐Mei Yan ₂ , Zhen‐Xing Ren ₁ , Yong‐Zhao Wang ₃ , Qiang Yu ₄ , Jun Xiong ₅ , Meng‐Liang Wang ₁

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An approach to 2,3‐dihydrobenzo[f]isoindolones by a Ag‐catalyzed Ugi 4CR/cascade radical cyclization sequence under mild conditions has been developed. The reaction of (E)‐2‐benzylidene‐4‐arylbut‐3‐ynoic acids, aldehydes, amines, and isocyanides produced 2,3‐dihydro‐benzo[f]isoindolones regioselectively in 60–85% yields via sequential Ugi 4CR/cascade radical cyclization reaction in the presence of Cs₂CO₃ and AgOTf. The method achieved the formation of two C−C bonds under air atmosphere in one‐pot fashion.

中文翻译：

Ag催化的连续Ugi 4CR /级联自由基环化反应区域选择性合成2,3-二氢苯并[f]异吲哚酮

已经开发了一种在温和条件下通过Ag催化的Ugi 4CR /级联自由基环化序列制备2,3-二氢苯并[ f ]异吲哚酮的方法。（E）-2-亚苄基-4-芳基丁-3-炔酸，醛，胺和异氰酸酯的反应通过连续的Ugi 4CR /选择性地产生60-85％的2,3-二氢苯并[ f ]异吲哚酮。 Cs ₂ CO ₃和AgOTf存在下进行级联自由基环化反应该方法以一锅法在空气气氛下实现了两个C-C键的形成。

更新日期：2021-02-16

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