Noninvasive screening for congenital heart defects using a serum metabolomics approach,Prenatal Diagnosis

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Noninvasive screening for congenital heart defects using a serum metabolomics approach
Prenatal Diagnosis ( IF 3 ) Pub Date : 2021-01-13 , DOI: 10.1002/pd.5893
Jacopo Troisi _{1,

2,

3} , Pierpaolo Cavallo _{4,

5} , Sean Richards _{6,

7} , Steven Symes _{7,

8} , Angelo Colucci ₁ , Laura Sarno ₉ , Annamaria Landolfi ₁ , Giovanni Scala _{2,

10} , David Adair ₇ , Carla Ciccone ₁₁ , Giuseppe M Maruotti ₉ , Pasquale Martinelli ₉ , Maurizio Guida _{1,

2,

9}

Affiliation

Department of Medicine and Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.
Metabolomics section, Theoreo Srl - Spin-off Company of the University of Salerno, Salerno, Italy.
Metabolomics section, European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.
Department of Physics, University of Salerno, Salerno, Italy.
Istituto Sistemi Complessi, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
Department of Biology, Geology and Environmental Sciences, University of Tennessee at Chattanooga, Chattanooga, Tennessee, USA.
Department of Obstetrics and Gynecology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
Department of Chemistry and Physics, University of Tennessee at Chattanooga, Chattanooga, Tennessee, USA.
Department of Neurosciences and Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
Hosmotic Srl, Naples, Italy.
Obstetrics and Gynecology clinic, G. Moscati Hospital, Avellino, Italy.

Heart anomalies represent nearly one‐third of all congenital anomalies. They are currently diagnosed using ultrasound. However, there is a strong need for a more accurate and less operator‐dependent screening method. Here we report a metabolomics characterization of maternal serum in order to describe a metabolomic fingerprint representative of heart congenital anomalies.

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