Nowadays, it is admitted to using of suitable carrier results in improving drug delivery such as nanotubes. So, multi-walled carbon nanotube (MWCNTs) has been proposed as a carrier (adsorbent) to improve the neurological Oxazepam (OZ) drug delivery. Freundlich, Temkin, and Langmuir isotherm models have been used in order to do assay adsorption of the OZ on the MWCNT. The maximum value of the isotherm constant (b = 0.14 L/mg) at 303 K temperature indicates stronger (better) adsorption of the OZ on the MWCNT surface in low concentrations (20 mg/L) and acidic pH; in fact, increasing of pH led to decreasing adsorption (60 → 35.91 mg/g) and dehydrogenation of the OZ drug. Reaching to the equilibrium state after 90 min and negative value of the ∆H (−41.57 kJ/mol) shows that the OZ adsorption has fast kinetic and exothermic processes. These issues imply depending of the OZ adsorption on the OZ concentration and the weight of adsorbent in the adsorption process.

中文翻译：

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奥沙西m药物在多壁碳纳米管上的动力学和热力学吸附

如今，人们公认使用合适的载体可以改善药物的输送，例如纳米管。因此，已经提出了多壁碳纳米管（MWCNT）作为载体（吸附剂）以改善神经系统奥沙西m（OZ）药物的递送。为了测定OZ在MWCNT上的吸附，已使用Freundlich，Temkin和Langmuir等温线模型。在303 K温度下，等温常数的最大值（b = 0.14 L / mg）表明，在低浓度（20 mg / L）和酸性pH下，OZ在MWCNT表面上的吸附更强（更好）。实际上，pH的升高会导致OZ药物的吸附降低（60→35.91 mg / g）和脱氢。90分钟后达到平衡状态且∆ H为负值（-41.57 kJ / mol）表明OZ吸附具有快速的动力学和放热过程。这些问题暗示着OZ吸附取决于OZ浓度和吸附过程中吸附剂的重量。