The debate on the biological effects of radiofrequency radiation (RFR) still continues due to differences in the design of studies (frequency, power density, specific absorption rate [SAR], exposure duration, cell, tissue, or animal type). The current study aimed to investigate the effects of 2,600 MHz RFR and melatonin on brain tissue biochemistry and histology of male rats. Thirty‐six rats were divided into six groups randomly: cage‐control, sham, RFR, melatonin, sham melatonin, and RFR melatonin. In RFR groups, animals were exposed to 2,600 MHz RFR for 30 days (30 min/day, 5 days/week) and the melatonin group animals were subcutaneously injected with melatonin (7 days/week, 10 mg/kg/day) for 30 days. SAR in brain gray matter was calculated as 0.44 and 0.295 W/kg for 1 and 10 g averaging, respectively. RFR exposure decreased the GSH, GSH‐Px, and SOD levels and increased the MPO, MDA, and NOx levels (P < 0.005) significantly. RFR exposure also led to an increase in structural deformation and apoptosis in the brain tissue. This study revealed that exogenous high‐dose melatonin could reduce these adverse effects of RFR. Limiting RFR exposure as much as possible is recommended, and taking daily melatonin supplements may be beneficial. Bioelectromagnetics. © 2021 Bioelectromagnetics Society

中文翻译：

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2600 MHz射频辐射对雄性Wistar大鼠脑组织的影响及褪黑激素的神经保护作用

由于研究设计（频率、功率密度、比吸收率 [SAR]、暴露持续时间、细胞、组织或动物类型）的差异，关于射频辐射 (RFR) 生物效应的争论仍在继续。目前的研究旨在调查 2,600 MHz RFR 和褪黑激素对雄性大鼠脑组织生化和组织学的影响。将 36 只大鼠随机分为 6 组：笼对照、假手术、RFR、褪黑激素、假褪黑激素和 RFR 褪黑激素。在 RFR 组中，动物暴露于 2,600 MHz RFR 30 天（30 分钟/天，5 天/周），褪黑激素组动物皮下注射褪黑激素（7 天/周，10 毫克/千克/天）30天。对于 1 克和 10 克的平均值，脑灰质中的 SAR 分别计算为 0.44 和 0.295 W/kg。RFR 暴露降低了 GSH、GSH-Px、P  < 0.005) 显着。RFR 暴露还导致脑组织中结构变形和细胞凋亡的增加。这项研究表明，外源性高剂量褪黑激素可以减少 RFR 的这些不利影响。建议尽可能限制 RFR 暴露，每天服用褪黑激素补充剂可能是有益的。生物电磁学。© 2021 生物电磁学学会