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Is hyperpolarised gas magnetic resonance imaging a valid and reliable tool to detect lung health in cystic fibrosis patients? a cosmin systematic review
Journal of Cystic Fibrosis ( IF 5.4 ) Pub Date : 2021-01-14 , DOI: 10.1016/j.jcf.2020.12.020
Fatmah Mallallah 1 , Anna Packham 1 , Ellen Lee 1 , Daniel Hind 1
Affiliation  

This paper systematically reviewed the literature reporting the validity and reliability of hyperpolarised gas MRI as a marker of lung health in cystic fibrosis (CF). MEDLINE, EMBASE and grey literature were searched for studies assessing the measurement properties of hyperpolarised helium-3 or xenon-129 MRI. The COSMIN risk of bias tool was used to critically appraise eligible studies. Findings show hyperpolarised gas MRI was able to detect structural and functional abnormalities in the lungs, detect response to treatments, and is more sensitive than FEV1 in detecting ventilation defects in CF patients. There was moderately robust evidence for construct validity of hyperpolarised gas MRI, although evidence for other types of validity is currently low. Nonetheless, high quality studies concluded that hyperpolarised gas MRI is a reliable tool and test results are reproducible in CF patients. Hyperpolarised gas MRI is a promising tool for detecting early CF pulmonary disease and for longitudinal monitoring of CF.



中文翻译:

超极化气体磁共振成像是检测囊性纤维化患者肺部健康的有效且可靠的工具吗?Cosmin 系统评价

本文系统回顾了报告超极化气体 MRI 作为囊性纤维化 (CF) 肺部健康标志物的有效性和可靠性的文献。在 MEDLINE、EMBASE 和灰色文献中搜索了评估超极化氦 3 或氙 129 MRI 测量特性的研究。COSMIN 偏倚风险工具用于严格评估符合条件的研究。研究结果表明,超极化气体 MRI 能够检测到肺部的结构和功能异常,检测对治疗的反应,并且比 FEV 1更敏感用于检测 CF 患者的通气缺陷。超极化气体 MRI 的结构效度有中等强度的证据,尽管目前其他类型效度的证据很低。尽管如此,高质量的研究得出结论,超极化气体 MRI 是一种可靠的工具,并且测试结果在 CF 患者中是可重复的。超极化气体 MRI 是检测早期 CF 肺部疾病和纵向监测 CF 的有前途的工具。

更新日期:2021-01-14
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