In this study, poly(ε-caprolactone) particles containing resveratrol were developed employing the GAS antisolvent technique. A central composite design 2² evaluated the influence of polymer, resveratrol mass ratio (2:1, 1:1, 1:2), and pressure (100, 120, 140 bar) on encapsulation percentage, and efficiency. The values obtained for encapsulation efficiency and percentage of encapsulation at the best conditions attained were 99.34% and 65.31%. In addition, the statistical analysis showed that only the mass ratio had significantly affected the percentage of encapsulation, but neither variable significantly affected efficiency. Microparticles produced demonstrably heterogeneous characteristics and irregular morphology. However, this process did not change either the compound chemical structures or the resveratrol antioxidant activity. Microparticles maintained constant release for 48 h, and in thermal oxidative analysis, the difference between samples and control was 2.57 times smaller than the difference between pure resveratrol and the control sample.

在这项研究中，采用GAS反溶剂技术开发了含有白藜芦醇的聚（ε-己内酯）颗粒。中央复合设计2 ²评估了聚合物，白藜芦醇质量比（2：1、1：1、1：2）和压力（100、120、140 bar）对包封率和效率的影响。获得的包封效率和在最佳条件下的包封百分比的值为99.34％和65.31％。此外，统计分析表明，只有质量比显着影响封装百分比，而没有任何变量显着影响效率。微粒产生明显的异质性和不规则形态。但是，该过程既没有改变化合物的化学结构，也没有改变白藜芦醇的抗氧化活性。微粒保持恒定释放48小时，在热氧化分析中，样品与对照之间的差异为2。