Bryophyllum constitutes a subgenus within the genus Kalanchoe that contains several plant species used in traditional medicine worldwide for the treatment of several diseases. However, little is known about the phytoconstituents of Bryophyllum spp. and previous reports have pointed at their low in Planta concentrations of bioactive compounds. In this work, we take advantage of plant in vitro culture for the study of the phenolic compounds found in the aerial parts of Bryophyllum spp. and their associated bioactivities. Our results show that the induction of nutritional stress leads to an improved accumulation of phenolic compounds, mainly flavonols and anthocyanins, represented by myricetin and malvidin glycosides, respectively. This effect is mainly found for B. × houghtonii, whose hydroethanolic extracts promoted the highest antioxidant, cytotoxic and anti-inflammatory activities. In the case of cytotoxic activity, Bryophyllum extracts showed an enhanced activity against the MCF-7 human breast carcinoma cell line. Meanwhile, extracts from B. daigremontianum promoted a wide range of effectiveness against different bacterial and fungal strains. This study is committed to shed light about the phytochemical potential associated to this unexplored subgenus, with the aim of considering Bryophyllum spp. as a valuable source of bioactive compounds for their exploitation in food, cosmetic and pharmaceutical industries.

苔藓菌属属于甘蓝菜属的一个亚属，其中包含几种在世界范围内用于治疗多种疾病的传统医学中使用的植物物种。然而，很少有人知道的phytoconstituents Bryophyllum属。和以前的报告指出它们在植物中的生物活性化合物浓度低。在这项工作中，我们利用植物离体培养的酚类化合物的地上部分的研究发现Bryophyllumspp。及其相关的生物活性。我们的结果表明，营养应激的诱导导致酚类化合物（主要是黄酮醇和花青素）的积累得到改善，分别以杨梅素和麦维汀糖苷为代表。这种作用主要在B. × houghtonii中发现，其水乙醇提取物具有最高的抗氧化，细胞毒性和抗炎活性。在细胞毒性活性的情况下，苔藓植物提取物显示出针对MCF-7人乳腺癌细胞系的增强活性。同时，从B. daigremontianum中提取促进了针对不同细菌和真菌菌株的广泛功效。这项研究致力于揭示与该未开发的亚属有关的植物化学潜力，目的是考虑到苔藓植物。作为生物活性化合物在食品，化妆品和制药行业中开发的重要来源。