OBJECTIVE To determine the impact of aerobic exercise on maximal and submaximal cardiopulmonary responses and predictors of change in individuals with Parkinson's disease (PD). DESIGN Single-center, parallel-group, rater-blind study. SETTING Research laboratory PARTICIPANTS: Individual's with mild to moderate PD (N=100) INTERVENTION: Participants were enrolled in a trial evaluating the impact of cycling on PD and randomized to either voluntary exercise (VE), forced exercise (FE), or a no exercise, control group. The exercise groups were time and intensity matched and exercised 3x/week for eight weeks on a stationary cycle. MAIN OUTCOME MEASURE Cardiopulmonary responses were collected via gas analysis during a maximal graded exercise test at baseline and post intervention. RESULTS Exercise attendance, was 97% and 93% for the FE and VE group respectively. Average exercise HR reserve was 67% ± 11% for FE and 70% ± 10% for VE. No significant difference was present for change in VO2peak post intervention, even though the FE group had a 5% increase in VO2peak. Both the FE and VE groups had significantly higher %VO2 at VT then the control group compared to baseline values (p=0.04). Mean (95% CI) VO2 at VT was 5% (0.1%, 11%) higher in FE patients (p=0.04) and 7% (2%, 12%) higher in VE groups compared to controls. A stepwise linear regression model revealed that lower age, high exercise cadence, and lower baseline VO2peak were most predictive of improved VO2peak. The overall model was found to be significant, (p< 0.01). CONCLUSION Peak and submaximal cardiopulmonary function may improve after aerobic exercise in individuals with PD. Lower age, higher exercise cadence, and lower baseline VO2peak were most predictive of improved VO2peak in this exercise cohort. The improvements observed in aerobic capacity were gained after a relatively short aerobic cycling intervention.

中文翻译：

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有氧运动对心肺反应的影响和帕金森病患者变化的预测因素。

目的 确定有氧运动对最大和次最大心肺反应的影响以及帕金森病 (PD) 患者变化的预测因素。设计 单中心、平行组、评估者盲法研究。设置 研究实验室参与者：轻度至中度 PD 个体 (N=100) 干预：参与者参加了一项评估骑自行车对 PD 影响的试验，并随机分配到自愿运动 (VE)、强迫运动 (FE) 或无运动，对照组。运动组的时间和强度相匹配，并在固定周期内每周锻炼 3 次，持续八周。主要结果测量在基线和干预后的最大分级运动测试期间通过气体分析收集心肺反应。结果 锻炼出勤率，FE 和 VE 组分别为 97% 和 93%。FE 的平均运动 HR 储备为 67% ± 11%，VE 为 70% ± 10%。干预后 VO2peak 的变化没有显着差异，即使 FE 组的 VO2peak 增加了 5%。与基线值相比，FE 和 VE 组在 VT 时的 %VO2 显着高于对照组（p=0.04）。与对照组相比，FE 患者的 VT 平均 (95% CI) VO2 (p=0.04) 高 5% (0.1%, 11%)，VE 组高 7% (2%, 12%)。逐步线性回归模型显示，年龄越小、运动节奏快和基线 VO2peak 越低，最能预测 VO2peak 的改善。发现整体模型是显着的，(p<0.01)。结论 PD 患者进行有氧运动后，峰值和次极值心肺功能可能会得到改善。年龄较低，在该运动队列中，较高的运动节奏和较低的基线 VO2peak 最能预测 VO2peak 的改善。在相对较短的有氧循环干预后，观察到的有氧能力的改善得到了改善。