The absorption and depletion of dietary administered praziquantel (PZQ) were explored in greater amberjack, Seriola dumerili, a promising farmed fish species in the Mediterranean area and elsewhere. Greater amberjack weighing 84 g were fed once daily for 5 days on diets containing either 1.5 or 3.0 g/kg of PZQ to deliver dose rates of 30 or 60 mg/kg fish, respectively. During the first day, plasma samples were measured for PZQ concentration at 2, 4, 8 and 24 h post-feeding. On the other treatment days, blood (plasma), muscle plus skin and gills were collected daily 24 h post-administration. Praziquantel was rapidly absorbed into fish circulation as the maximum plasma concentration (C_max) was achieved at 8 h (3.0 μg/ml) and 2 h post administration (4.3 μg/ml) for the low and high dosing, respectively. The two-fold increase in dosing led to a significant dose-dependent effect between the mean PZQ concentrations of the two dosing regimens in most selected sampling points such as 2, 4, 24, 120 h. While the elimination half-life (t_1/2b) was shorter in high PZQ dosing (8.2 h) compared to that calculated for the low (15.1 h), depletion of PZQ from greater amberjack plasma was considered rapid on both trials, as its concentration fell to 0.31 (low) and 0.56 (high) μg/ml 24 h post-treatment. Elimination of PZQ was also rapid from the gills and muscle plus skin, with drug levels measured below the limit of quantification as early as 72 and 96 h post treatment, for the low and the high dosing, respectively. Overall, the high dosing regimen is preferable over the low dosing schedule since it was readily accepted and resulted in higher circulatory levels in greater amberjack. Moreover, the rapid elimination of PZQ from the body compartment of greater amberjack suggested a twice a day administration of medicated meals to ensure adequate drug circulatory levels.

在较大的a鱼（Seriola dumerili）中探索了饮食管理的吡喹酮（PZQ）的吸收和耗竭，这是地中海地区和其他地区的有前途的养殖鱼类。每天重饲一次重84克的较大的mber鱼，每天一次，饲喂1.5或3.0克/千克PZQ的饲料，持续5天，以分别提供30或60毫克/千克鱼的剂量。在第一天，在进食后2、4、8和24小时测量血浆样品的PZQ浓度。在其他治疗日，每天在给药后24小时收集血液（血浆），肌肉，皮肤和g。吡喹酮以最大血浆浓度（C _max低剂量和高剂量分别在给药后8 h（3.0μg/ ml）和2 h（4.3μg/ ml）达到）。在大多数选定的采样点（例如2、4、24、120小时），两种剂量方案的平均PZQ浓度之间的两倍增加导致了显着的剂量依赖性效应。而消除半衰期（t _{1 / 2b}）在高剂量PZQ（8.2 h）中比在低剂量（15.1 h）中计算的要短，在两个试验中都认为从较大的琥珀色血浆中耗尽PZQ很快，因为其浓度分别降至0.31（低）和0.56（高）。 ）μg/ ml（治疗后24小时）。腮，肌肉和皮肤中PZQ的消除也很快，分别在低剂量和高剂量时，分别在治疗后72和96 h时，药物水平低于定量限。总体而言，高剂量方案比低剂量方案更可取，因为它很容易被接受并导致更大的a鱼有较高的循环水平。此外，从较大的mber鱼体腔中迅速清除PZQ的建议，建议每天两次服用药膳以确保足够的药物循环水平。