Our aim was to evaluate the utility of the neonatal early-onset sepsis risk calculator (NEOSC) to the utility of C-reactive protein (CRP) for diagnosing neonatal EOS. This retrospective study reviewed the records of neonates who underwent sepsis workups due to equivocal symptoms and compared their CRP values to the calculator’s recommendations and their cultures. A total of 382 newborns who underwent sepsis work-up due to equivocal symptoms were included in our study. The calculator’s recommendations would have reduced the number of newborns who underwent sepsis workups by 82.5% and antibiotic treatment by 83.4% (n = 315). Considering that 373 of 382 (97.6%) ultimately had no sepsis, the calculator’s specificity was higher than that of CRP (83.9% versus 76.1%). When comparing the maximal CRP value with the risk according to the neonatal sepsis calculator, a significant correlation was found between them (P < 0.01), but the relationship was not strong (Pearson’s correlation = 0.27). We found a significant correlation between the risk of sepsis according to the NEOSC and the CRP values, although the correlation was not strong. The calculator’s high specificity enables safe avoidance of multiple blood tests and antibiotic treatments for suspected neonates who are not infected. CRP tests can reduce the number of infected newborns the calculator may miss, at the cost of unnecessary blood tests and antibiotic therapy to many newborns.

我们的目的是评估新生儿早发性败血症风险计算器 (NEOSC) 对 C 反应蛋白 (CRP) 诊断新生儿 EOS 的效用。这项回顾性研究审查了由于模棱两可的症状而接受败血症检查的新生儿的记录，并将他们的 CRP 值与计算器的建议和他们的文化进行了比较。我们的研究共纳入了 382 名因症状不明而接受败血症检查的新生儿。计算器的建议将使接受败血症检查的新生儿数量减少 82.5%，抗生素治疗减少 83.4%（n = 315）。考虑到 382 人中的 373 人 (97.6%) 最终没有败血症，计算器的特异性高于 CRP（83.9% 对 76.1%）。根据新生儿败血症计算器将最大 CRP 值与风险进行比较时，发现它们之间存在显着相关性（P < 0.01)，但相关性不强（Pearson 相关系数 = 0.27）。我们发现根据 NEOSC 的败血症风险与 CRP 值之间存在显着相关性，尽管相关性不强。计算器的高特异性可以安全地避免对未感染的疑似新生儿进行多次血液检查和抗生素治疗。CRP 测试可以减少计算器可能遗漏的受感染新生儿的数量，但代价是对许多新生儿进行不必要的血液检查和抗生素治疗。