Pseudozyma sp. are yeasts that are commercially important due to their production of glycolipid biosurfactants, squalene, itaconic acid, and exopolysaccharide. The search for other analgesia inducing drugs, such as opiates and non-steroidal anti-inflammatory drugs (NSAIDs), as alternatives is beneficial. In this study, the antinociceptive and anti-inflammatory actions of α-d-mannan were studied using acetic acid-induced writhing, open field test, formalin test, and carrageenan-induced paw oedema tests in mice. The α-d-mannan obtained from Pseudozyma sp. was confirmed by methylation analysis, 1D and 2D NMR spectroscopic analysis, and GC–MS. The results show that α-d-mannan from Pseudozyma sp. has analgesic and anti-inflammatory activities.

假酵母属sp.是具有商业重要性的酵母，因为它们生产糖脂生物表面活性剂、角鲨烯、衣康酸和胞外多糖。寻找其他镇痛诱导药物，如阿片类药物和非甾体抗炎药 (NSAID) 作为替代品是有益的。在本研究中，通过乙酸诱导的小鼠扭体、旷场试验、福尔马林试验和角叉菜胶诱导的爪水肿试验，研究了α- d-甘露聚糖的镇痛和抗炎作用。从Pseudozyma sp. 获得的 α- d-甘露聚糖。通过甲基化分析、一维和二维核磁共振波谱分析以及GC-MS 证实。结果表明，来自Pseudozyma sp. 的 α- d-甘露聚糖。具有镇痛和抗炎活性。