Background Poor adherence to treatment is one of the main challenges to symptom control and preventing recurrence in bipolar disorder (BD). Numerous studies have established an association between patients’ poor adherence and an increased risk of recurrence, relapse of the symptoms and admission to hospital. Aim To study the socio-demographic and clinical factors associated with medication nonadherence in patients with BD who were admitted to the hospital. Setting The study was conducted at the Institute of Psychiatry, Ain Shams University. Methods A 1-year longitudinal prospective study of 110 patients, aged 18–60 years, with BD-I. Young Mania Rating Scale, Clinical Global Impression, Global Assessment of Functioning, Sheehan Disability Scale and Insight and Treatment Attitude Questionnaire were applied before and 6 months after discharge. Adherence was measured using the Morisky 8-Item Medication Adherence Scale. Sociodemographic data and level of functioning were studied in relation to adherence. Results Higher adherence was noticed in female, married and older patients and those with a higher level of education. However, low adherence was more common in male, non-married and less educated patients. Follow-up after 6 months revealed that the high adherence group scored the lowest in terms of disability. Meanwhile, the low adherence group scored the highest scores in disability. Conclusion Several socio-demographic and clinical variables were found to be associated with a low adherence rate to the prescribed medication in patients with BD-I. Age and impaired insight were found to be significant predictive factors for non-adherence.

中文翻译：

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埃及一所大学医院 I 型双相情感障碍患者服药依从性的心理人口统计学和临床​​预测因素


背景 治疗依从性差是双相情感障碍 (BD) 症状控制和预防复发的主要挑战之一。许多研究已证实患者依从性差与复发、症状复发和入院风险增加之间存在关联。目的 研究与入院的 BD 患者不依从药物治疗相关的社会人口统计学和临床​​因素。背景 这项研究是在艾因夏姆斯大学精神病学研究所进行的。方法 对 110 名年龄在 18-60 岁的 BD-I 患者进行为期 1 年的纵向前瞻性研究。出院前和出院后 6 个月应用青年躁狂评定量表、临床总体印象、总体功能评估、希恩残疾量表以及洞察力和治疗态度问卷。使用 Morisky 8 项药物依从量表测量依从性。研究了社会人口统计数据和功能水平与依从性的关系。结果女性、已婚、老年患者以及受教育程度较高的患者依从性较高。然而，低依从性在男性、未婚和受教育程度较低的患者中更为常见。 6 个月后的随访显示，高依从性组在残疾方面得分最低。与此同时，低依从性组在残疾方面得分最高。结论 发现一些社会人口统计学和临床​​变量与 BD-I 患者对处方药物的低依从率相关。研究发现，年龄和洞察力受损是不依从的重要预测因素。