Objective: 2D:4D ratio is determined by the balance between androgens to estrogens. Low level estrogen reduces bone mineral density (BMD) and incurs negative changes to bone microarchitecture, increasing the risk of osteoporosis and, as a consequence, fracture risk in women. The purpose of this study was to investigate the relationship between 2D:4D, muscle strength and body composition to BMD in young women. Methods: 127 young women with the age range of 24-36 yr voluntarily participated in this study. Lengths of the second (index) and fourth (ring) fingers, upper and lower body strength and body composition (body mass index (BMI), waist to hip ratio (WHR), body fat percentage) were estimated. Also, blood levels of calcium and 25-hydroxyvitamin D (25OHD) were evaluated and dual-energy X-ray absorptiometry device was used to measure BMD in the lumbar spine (LS) and femoral neck (FN). Results: The results showed that digit ratios, upper body and lower body muscle strength, BMI and fat percentage had a positive relationship with LS and FN BMDs (P˂ 0.05). In addition, there was no significant relationship between WHR and the BMD of LS and FN. Multiple linear regression analysis showed that upper and lower body strength were stronger determinant of BMD LS and FN. Conclusion: Based on the results, the researchers concluded that upper and lower body strength, 2D:4D ratios and BMI are important factors on predict young women’s BMD. Also, it seems that some of these factors may be able to predict the osteoporosis potential in the young women.

中文翻译：

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青年女性的第二至四位数比例（2D：4D），肌肉力量和身体成分与骨矿物质密度之间的关系

目的：2D：4D比例取决于雄激素与雌激素之间的平衡。低水平的雌激素会降低骨矿物质密度（BMD），并对骨微结构产生负面影响，从而增加骨质疏松症的风险，并因此增加女性骨折的风险。这项研究的目的是调查年轻女性中2D：4D，肌肉力量和身体成分与BMD的关系。方法：127名年龄在24-36岁之间的年轻女性自愿参加了这项研究。估计第二根（食指）和第四根（无名指）的长度，上下身体的力量和身体成分（体重指数（BMI），腰臀比（WHR），体脂百分比）。也，评估血钙和25-羟基维生素D（25OHD）的水平，并使用双能X线吸收仪测量腰椎（LS）和股骨颈（FN）中的BMD。结果：结果显示，数字比率，上半身和下半身的肌肉力量，BMI和脂肪百分比与LS和FN BMD呈正相关（P˂0.05）。此外，WHR与LS和FN的BMD之间没有显着关系。多元线性回归分析显示，上，下体强度是BMD LS和FN的更强决定因素。结论：根据研究结果，研究人员得出结论，上下体强度，2D：4D比率和BMI是预测年轻女性BMD的重要因素。同样，这些因素中的一些似乎可以预测年轻女性的骨质疏松症潜力。