This study examined the effects of a 6-week repeated sprint training program on redox-based homeostasis and its association with muscle damage. Fifteen male physical education students (aged 20.0 ± 1.0 years; body weight 77.7 ± 6.0 kg; height 181.0 ± 4.4 cm; % body fat 8.7 ± 3.0 %) familiar with intermittent activities volunteered to participate in the study. Experimental training program consisted of 2-3 sets of 6-10 straight-line or shuttle 20-meter repeated sprints with departures every 25 seconds and 2-minute inter-set passive recovery. The training intervention lasted for six weeks during which 18 training sessions were performed. The levels of 15-F2t-isoprostanes were measured in plasma and 24-hour urine; superoxide dismutase, glutathione peroxidase and glutathione reductase in erythrocytes; uric acid and creatine kinase in serum after; the first, and the penultimate training session. The level of muscle damage following repeated sprint exercise was not significantly altered (402 to 496 U/L; p=.151) and had no significant associations with changes in marker depicting redox-homeostasis. A significant increase in plasma 15-F2t-isoprostanes (0.32 to 0.56 ng/mL; p=.026), and subsequent decrease in glutathione reductase (1070.4 to 502.9 U/g Hb; p<.001) were observed. Urinary 15-F2t-isoprostane levels were 25% greater in post-training, although this increase did not reach statistical significance. These results indicate that repeated sprint training program stimulates the equilibrium in redox homeostasis developing antioxidant protection to the constantly increasing training load.

中文翻译：

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反复冲刺训练后氧化还原稳态的改变

这项研究检查了为期6周的重复冲刺训练计划对基于氧化还原的稳态及其与肌肉损伤的关系的影响。十五名男性体育学生（年龄20.0±1.0岁；体重77.7±6.0公斤；身高181.0±4.4厘米；体脂百分比8.7±3.0％）自愿参加这项研究。实验训练计划包括2-3套6-10的直线或20米往返短跑重复冲刺，每25秒出发一次，每2分钟进行一组被动恢复。培训干预持续了六个星期，在此期间进行了18次培训。测量血浆和24小时尿液中15-F2t-异前列腺素的水平；红细胞中的超氧化物歧化酶，谷胱甘肽过氧化物酶和谷胱甘肽还原酶；血清后尿酸和肌酸激酶；第一次，倒数第二次培训。重复冲刺运动后的肌肉损伤水平没有明显改变（402至496 U / L； p = .151），并且与氧化还原稳态的标记变化没有显着相关性。观察到血浆15-F2t-异前列腺素显着增加（0.32至0.56 ng / mL； p = .026），随后谷胱甘肽还原酶降低（1070.4至502.9 U / g Hb； p <.001）。训练后尿中15-F2t-异前列腺素水平增加了25％，尽管这种增加没有达到统计学意义。这些结果表明，重复的冲刺训练程序可以刺激氧化还原稳态的平衡，从而为不断增加的训练负荷提供抗氧化保护。重复冲刺运动后的肌肉损伤水平没有明显改变（402至496 U / L； p = .151），并且与氧化还原稳态的标记变化没有显着相关性。观察到血浆15-F2t-异前列腺素显着增加（0.32至0.56 ng / mL； p = .026），随后谷胱甘肽还原酶降低（1070.4至502.9 U / g Hb； p <.001）。训练后尿中15-F2t-异前列腺素水平增加了25％，尽管这种增加没有达到统计学意义。这些结果表明，重复的冲刺训练程序可以刺激氧化还原稳态的平衡，从而为不断增加的训练负荷提供抗氧化保护。重复冲刺运动后的肌肉损伤水平没有明显改变（402至496 U / L； p = .151），并且与氧化还原稳态的标记变化没有显着相关性。观察到血浆15-F2t-异前列腺素显着增加（0.32至0.56 ng / mL； p = .026），随后谷胱甘肽还原酶降低（1070.4至502.9 U / g Hb； p <.001）。训练后尿中15-F2t-异前列腺素水平增加了25％，尽管这种增加没有达到统计学意义。这些结果表明，重复的冲刺训练程序可以刺激氧化还原稳态的平衡，从而为不断增加的训练负荷提供抗氧化保护。观察到血浆15-F2t-异前列腺素显着增加（0.32至0.56 ng / mL； p = .026），随后谷胱甘肽还原酶降低（1070.4至502.9 U / g Hb； p <.001）。训练后尿中15-F2t-异前列腺素水平增加了25％，尽管这种增加没有达到统计学意义。这些结果表明，重复的冲刺训练程序可以刺激氧化还原稳态的平衡，从而为不断增加的训练负荷提供抗氧化保护。观察到血浆15-F2t-异前列腺素显着增加（0.32至0.56 ng / mL； p = .026），随后谷胱甘肽还原酶降低（1070.4至502.9 U / g Hb； p <.001）。训练后尿中15-F2t-异前列腺素水平增加了25％，尽管这种增加没有达到统计学意义。这些结果表明，重复的冲刺训练程序可以刺激氧化还原稳态的平衡，从而为不断增加的训练负荷提供抗氧化保护。