OBJECTIVE In academic settings around the world, there is a resurgence of interest in using psychedelic substances for the treatment of addictions, posttraumatic stress disorder, depression, anxiety, and other diagnoses. This case series describes the medical consequences of accidental overdoses in three individuals. METHOD Case series of information were gathered from interviews, health records, case notes, and collateral reports. RESULTS The first case report documents significant improvements in mood symptoms, including reductions in mania with psychotic features, following an accidental lysergic acid diethylamide (LSD) overdose, changes that have been sustained for almost 20 years. The second case documents how an accidental overdose of LSD early in the first trimester of pregnancy did not negatively affect the course of the pregnancy or have any obvious teratogenic or other negative developmental effects on the child. The third report indicates that intranasal ingestion of 550 times the normal recreational dosage of LSD was not fatal and had positive effects on pain levels and subsequent morphine withdrawal. CONCLUSIONS There appear to be unpredictable, positive sequelae that ranged from improvements in mental illness symptoms to reduction in physical pain and morphine withdrawal symptoms. Also, an LSD overdose while in early pregnancy did not appear to cause harm to the fetus.

中文翻译：

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LSD过量：三例报告

目的在世界各地的学术环境中，对使用迷幻药物治疗成瘾，创伤后应激障碍，抑郁症，焦虑症和其他诊断的兴趣重新兴起。本案例系列描述了三个人意外用药过量的医疗后果。方法从访谈，健康记录，病例记录和附带报告中收集病例系列信息。结果第一个病例报告表明，在意外的麦角酸二乙酰胺（LSD）过量服用后，情绪症状有了明显改善，包括精神病性躁狂症减少，这种改变持续了近20年。第二个案例记录了在怀孕的头三个月初期意外过量服用LSD不会对怀孕过程产生负面影响或对孩子产生任何明显的致畸或其他负面发育影响的情况。第三份报告指出，鼻内摄入LSD正常娱乐剂量的550倍并不致命，并且对疼痛水平和随后的吗啡戒断有积极作用。结论似乎存在不可预测的积极后遗症，其范围从精神疾病症状的改善到身体疼痛和吗啡戒断症状的减轻。另外，在怀孕初期服用过量的LSD似乎不会对胎儿造成伤害。第三份报告指出，鼻内摄入LSD正常娱乐剂量的550倍并不致命，并且对疼痛水平和随后的吗啡戒断有积极作用。结论似乎存在不可预测的积极后遗症，其范围从精神疾病症状的改善到身体疼痛和吗啡戒断症状的减轻。另外，在怀孕初期服用过量的LSD似乎不会对胎儿造成伤害。第三份报告指出，鼻内摄入LSD正常娱乐剂量的550倍并不致命，并且对疼痛水平和随后的吗啡戒断有积极作用。结论似乎存在不可预测的积极后遗症，其范围从精神疾病症状的改善到身体疼痛和吗啡戒断症状的减轻。另外，在怀孕初期服用过量的LSD似乎不会对胎儿造成伤害。