OBJECTIVE The present study updates prior research, incorporating state-level administrative data to examine associations between self-reported history of alcohol dependence and birth record-derived reproductive onset, the latter assessed through peak childbearing years. METHOD Participants included 542 African ancestry (AA) and 2,928 European or other ancestry (EA) female twins ascertained through Missouri birth records and recruited as part of a birth cohort study of like-sex female pairs born between 1975 and 1985. Analyses were limited to twins for whom residence in Missouri when of reproductive age could be documented, including twins who left Missouri but later returned. Cox proportional hazards regression models were estimated predicting age at first childbirth from history of alcohol dependence, separately for AA and EA twins, without and with adjustment for sociodemographic characteristics, comorbid psychopathology and other substance involvement, overweight/obesity status, and family-of-origin and childhood risk factors. RESULTS Among EA twins, alcohol dependence predicted both early and delayed childbearing; in adjusted models, alcohol dependence was associated with overall delayed childbearing. Associations between alcohol dependence and reproductive onset were nonsignificant among AA twins. CONCLUSIONS Findings for EA twins are consistent with the broader literature indicating increased risk of teen motherhood associated with early-onset and problem drinking, but suggest that this may be explained by other correlated risk factors. The more robust finding, confirming relatively recent research, is of delayed childbearing associated with alcohol dependence.

中文翻译：

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妇女对酒精的依赖和生殖疾病，更新：对研究和国家级行政数据的分析

目的本研究更新了先前的研究，纳入了州级行政数据以检查自我报告的酒精依赖史与出生记录衍生的生殖发作之间的关联，后者是通过生育高峰期评估的。方法参与者包括542名非洲血统（AA）和2,928名欧洲或其他血统（EA）的女性双胞胎，这些双胞胎是通过密苏里州的出生记录确定的，并被招募为对1975年至1985年之间出生的同性女性配对进行的队列研究。可以证明在育龄时居住在密苏里州的双胞胎，包括离开密苏里州但后来返回的双胞胎。根据Ax和EA双胞胎的酒精依赖史，估算了Cox比例风险回归模型来预测首次分娩的年龄，无需调整社会人口统计学特征，合并症的精神病理学和其他物质参与，超重/肥胖状况以及原籍家庭和儿童期的危险因素。结果在EA双胞胎中，酒精依赖可预测早育和延迟生育。在调整后的模型中，酒精依赖与整体生育延迟有关。酒精依赖与生殖发作之间的关联在AA双胞胎中不显着。结论EA双胞胎的发现与更广泛的文献一致，这些文献表明与早发和饮酒有关的青少年孕产的风险增加，但提示这可能是由其他相关的危险因素引起的。更可靠的发现证实了最近的研究结果，即与酒精依赖相关的生育延迟。