Stereoselective and applications of spirocyclic oxindoles,Organic Chemistry Frontiers

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Stereoselective and applications of spirocyclic oxindoles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-1-6 , DOI: 10.1039/d0qo01085e
Alexander J. Boddy _{1,

2,

3,

4,

5} , James A. Bull _{1,

2,

3,

4,

5}

Affiliation

The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3- to 8-membered rings. It highlights the importance of these structures for applications in medicinal chemistry, as intermediates or final products in total synthesis and as model compounds for the development of enantioselective catalytic methodologies.

中文翻译：

螺环羟吲哚的立体选择性及其应用

以立体选择性的方式形成新的化学实体的新型合成策略的发展是有机和药物化学中正在进行的重要目标。这篇综述分析了新的立体选择方法对螺环3到8元环的螺环羟吲哚的发展。它强调了这些结构对于药物化学应用，作为全合成中的中间体或最终产品以及作为开发对映选择性催化方法的模型化合物的重要性。

更新日期：2021-01-13

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