Bulk-heterojunction photocapacitors with high open-circuit voltage for low light intensity photostimulation of neurons,Journal of Materials Chemistry C

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Bulk-heterojunction photocapacitors with high open-circuit voltage for low light intensity photostimulation of neurons
Journal of Materials Chemistry C ( IF 5.7 ) Pub Date : 2021-1-13 , DOI: 10.1039/d0tc03477k
Shashi Bhushan Srivastava _{1,

2,

3,

4} , Rustamzhon Melikov _{1,

2,

3,

4} , Erdost Yildiz _{2,

3,

4,

5} , Ugur Meric Dikbas _{2,

3,

4,

6,

7} , Sadra Sadeghi _{2,

3,

4,

8} , Ibrahim Halil Kavakli _{2,

3,

4,

6,

7} , Afsun Sahin _{2,

3,

4,

5,

9} , Sedat Nizamoglu _{1,

2,

3,

4,

10}

Affiliation

High-level transduction control of light to bioelectricity is an important goal for the realization of superior neuron-device interfaces that can be used for regulating fundamental cellular processes to cure neurological disorders. In this study, a single-junction, wireless, and capacitive-charge-injecting optoelectronic biointerface with negligible faradaic reactions by using a high open-circuit voltage (0.75 V) bulk heterojunction of PTB7-Th:PC71BM is designed and demonstrated. The biointerface generates a 2-fold higher photocurrent in comparison with P3HT:PC61BM having an open-circuit voltage of 0.55 V. Furthermore, we observed that light intensity is logarithmically correlated with the open-circuit voltage of solar cells, and the photovoltage of the biointerfaces varies the switching speed of capacitive charge-transfer. Finally, pulse trains of capacitive stimuli at a low light intensity of 20 mW cm⁻² elicit action potential generation in primary hippocampal neurons extracted from E15–E17 Wistar Albino rats. These findings show the great promise of high open-circuit voltage bulk heterojunction biointerfaces for non-genetic, all-optical and safe modulation of neurons.

中文翻译：

具有高开路电压的块状异质结光电电容器，用于神经元的低光强度光刺激

光到生物电的高水平传导控制是实现高级神经元设备界面的重要目标，该界面可用于调节基本的细胞过程以治疗神经系统疾病。在这项研究中，通过使用PTB7-Th：PC71BM的高开路电压（0.75 V）本体异质结，设计并演示了具有可忽略的法拉第反应的单结，无线和注入电容电荷的光电生物接口。与具有0.55 V开路电压的P3HT：PC61BM相比，该生物界面产生的光电流高2倍。此外，我们观察到光强度与太阳能电池的开路电压呈对数相关，并且光强度与太阳能电池的开路电压成对数关系。生物接口改变电容性电荷转移的开关速度。最后，⁻²在从E15–E17 Wistar Albino大鼠中提取的原代海马神经元中引起动作电位的产生。这些发现表明，高开路电压体异质结生物界面对神经元的非遗传，全光学和安全调制具有很大的希望。

更新日期：2021-01-13

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