Highly porous and elastic aerogel based on ultralong hydroxyapatite nanowires for high-performance bone regeneration and neovascularization,Journal of Materials Chemistry B

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Highly porous and elastic aerogel based on ultralong hydroxyapatite nanowires for high-performance bone regeneration and neovascularization
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-1-6 , DOI: 10.1039/d0tb02288h
Gao-Jian Huang ₁ , Han-Ping Yu ₂ , Xue-Lian Wang ₁ , Bing-Bing Ning ₁ , Jing Gao ₁ , Yi-Qin Shi ₃ , Ying-Jie Zhu ₂ , Jun-Li Duan ₁

Affiliation

Hydroxyapatite (HAP) is promising for the clinical treatment of bone defects because of its excellent biocompatibility and osteo-conductivity. However, highly porous HAP scaffolds usually exhibit high brittleness and poor mechanical properties, thus organic constituents are usually added to form composite materials. In this work, a highly porous and elastic aerogel made from ultralong HAP nanowires with ultrahigh porosity (∼98.5%), excellent elasticity and suitable porous structure is prepared as the high-performance scaffold for bone defect repair. The highly porous structure of the as-prepared aerogel is beneficial to bone ingrowth and matter/fluid transfer, and the high elasticity can ensure the structural integrity of the scaffold during bone regeneration. Therefore, the HAP nanowire aerogel scaffold can promote the adhesion, proliferation and migration of rat bone marrow derived mesenchymal stem cells (rBMSCs), and elevate the protein expression of osteogenesis and angiogenesis related genes. The in vivo experimental results demonstrate that the HAP nanowire aerogel scaffold is favorable for the ingrowth of new bone and blood vessels, and thus can greatly accelerate bone regeneration and neovascularization. The as-prepared HAP nanowire aerogel scaffold shows promising potential for biomedical applications such as bone defect repair.

中文翻译：

基于超长羟基磷灰石纳米线的高多孔弹性气凝胶用于高性能骨再生和新血管形成

羟基磷灰石（HAP）因其优异的生物相容性和骨传导性而有望用于骨缺损的临床治疗。然而，高度多孔的HAP支架通常表现出高脆性和较差的机械性能，因此通常添加有机成分形成复合材料。在这项工作中，由具有超高孔隙率（~98.5%）、优异弹性和合适多孔结构的超长 HAP 纳米线制成的高度多孔和弹性气凝胶被制备为用于骨缺损修复的高性能支架。所制备的气凝胶的高度多孔结构有利于骨向内生长和物质/流体转移，高弹性可以确保骨再生过程中支架的结构完整性。因此，HAP 纳米线气凝胶支架可以促进粘附，大鼠骨髓间充质干细胞（rBMSCs）的增殖和迁移，并提高成骨和血管生成相关基因的蛋白表达。这体内实验结果表明，HAP纳米线气凝胶支架有利于新骨和血管的向内生长，从而可以大大加速骨再生和新生血管的形成。所制备的 HAP 纳米线气凝胶支架显示出在生物医学应用（如骨缺损修复）方面的潜力。

更新日期：2021-01-13

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