Nanoscience has established itself as an interdisciplinary, integrated science that achieved significant translational outcomes in 2020, the fruition of many years of dedicated work resulting in high-performance masks worn by many, and liposomal mRNA vaccines against the virus responsible for COVID-19. The global pandemic brought into stark relief the necessary long-term investments in fundamental research that are required to meet today’s challenges. Also, what was made crystal clear in 2020 is that solutions to complex problems require a confluence of expertise from a diverse range of scientists, engineers, and entrepreneurs. Nanotechnology has never been more important than it is now. 2021 marks the 20-year anniversary of the first published issue of Nano Letters. In view of this modern platinum celebration, I want to take the opportunity to reflect on how nanomaterials and applications have evolved hand-in-glove over the past two decades. All the while, Nano Letters has contributed to defining these global trends. Our top-cited article in 2001 focused on colloidal semiconducting CdSe and CdSe/ZnS quantum dots and their high photoluminescence properties.(1) The synthesis of crystalline Ag nanowires(2) was the highest in 2002, followed by the demonstration of Si nanowire field-effect transistors(3) in 2003. The next three years saw the application of nanomaterials in medicine, from cytotoxicity studies of quantum dots(4) to gold nanorods that could identify cancer cells(5) to how the shape and size of gold nanoparticles affected uptake in cells.(6) We returned to devices in 2007 with the design of ZnO nanowire photodetectors.(7) Starting in 2008, atomic materials came to the forefront with our top-cited paper on the thermal conductivity of graphene(8) and then the growth of graphene on different substrates(9) in 2009. In 2010, photoluminescence of monolayer MoS₂(10) was of high interest, and then in 2011 was the optical response from solutions of MoS₂ nanoplates.(11) 2012 saw the generation of graphene quantum dots for bioimaging.(12) 2013 and 2014 marked a focus on solar cell designs based on inorganic–organic nanostructured materials and hybrid halide perovskites.(13,14) In 2015, the top-cited work was the synthesis of cesium lead halide perovskite nanocrystals.(15) Energy-based applications, and especially batteries, occupied the top-cited papers in 2016–2018 related to polysulfide redox in lithium–sulfur batteries, electrodeposition of lithium metal on electrodes for lithium–metal batteries, and nanowire cathodes for zinc-ion batteries.(16−18) Although it is still early, 2019 and 2020 have highlighted luminescent afterglow organic and polymer probes for image-guided cancer surgery and single-atom catalysis for lithium–sulfur batteries.(19,20) How do these top-cited trends compare to usage data? This comparison is interesting. Although both metrics define journal leadership, when the top-cited paper is not the same as the most accessed in a year, which is about 50% of the time for our first two decades,then the community has a window into what future work might be of high impact. Some of our most accessed papers in their year include phospholipid bilayer nanoparticles(21) in 2002 and high-efficiency air filters based on silver nanowire percolation networks(22) in 2017. These concepts resonate strongly today, especially as nanoscience and nanotechnology continue to contribute to COVID-19 and other solutions. In 2020, and new for Nano Letters, we launched Viewpoints,(23) opinion pieces by eminent scholars who mused on what the next 20 years of nanoscience and nanotechnology might look like. I highly encourage you to read these short articles on ideas related to computation and nano-optics,(24−26) nanosafety and nanomedicine,(27−29) batteries and inorganic nanomaterials,(30,31) molecular nanomaterials,(32−34) DNA nanotechnology,(35,36) and more. The nanoscience 20-year roadmap is made by people: our curiosities and discoveries applied to societal needs and environmental problems. I am optimistic for the future of nanoscience and the role that Nano Letters will continue to play; please join us in this exciting effort. Views expressed in this editorial are those of the author and not necessarily the views of the ACS. This article references 36 other publications.

中文翻译：

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庆祝Nano Letters 20年

纳米科学已经确立为一门跨学科的综合科学，并在2020年实现了重要的翻译成果，多年的专门工作取得了成果，许多人戴着了高性能的口罩，并制成了针对COVID-19病毒的脂质体mRNA疫苗。全球流行病使为应对当今挑战而需要的基础研究方面的必要长期投资变得无足轻重。同样，在2020年明确明确的是，要解决复杂问题，就需要融合来自众多科学家，工程师和企业家的专业知识。纳米技术从未像现在这样重要。2021年是Nano Letters首次出版发行20周年。鉴于这次现代铂金庆祝活动，我想借此机会回顾一下过去二十年来纳米材料及其应用如何演变为手套。一直以来，纳米字母为定义这些全球趋势做出了贡献。我们在2001年引用最多的文章集中于胶体半导体CdSe和CdSe / ZnS量子点及其高光致发光性能。（1）晶体银纳米线的合成（2）在2002年是最高的，其次是硅纳米线场的演示效应晶体管（3）于2003年出现。在接下来的三年中，纳米材料在医学中的应用从量子点的细胞毒性研究（4）到可以识别癌细胞的金纳米棒（5）以及金纳米粒子的形状和大小如何影响细胞的摄取。（6）我们在2007年以ZnO纳米线光电探测器的设计返回设备。（7）从2008年开始，₂（10）是人们关注的焦点，然后在2011年是MoS ₂溶液的光学响应20）这些热门趋势与使用情况数据相比如何？这种比较很有趣。尽管这两个指标都定义了期刊的领导力，但是当被引用次数最多的论文与一年中被引用次数最多的论文不同时（这是我们前二十年的大约50％的时间），那么社区就可以了解未来的工作范围具有很高的影响力。本年度访问量最大的论文包括2002年的磷脂双层纳米颗粒（21）和2017年基于银纳米线渗滤网络的高效空气过滤器（22）。这些概念在今天引起了强烈共鸣，特别是随着纳米科学和纳米技术的不断发展到COVID-19和其他解决方案。2020年，在我们最初的二十年中，这大约占50％的时间，然后社区就可以了解未来的工作可能产生的巨大影响。本年度访问量最大的论文包括2002年的磷脂双层纳米颗粒（21）和2017年基于银纳米线渗滤网络的高效空气过滤器（22）。这些概念在今天引起了强烈共鸣，特别是随着纳米科学和纳米技术的不断发展到COVID-19和其他解决方案。2020年，在我们最初的二十年中，这大约占50％的时间，然后社区就可以了解未来的工作可能产生的巨大影响。本年度访问量最大的论文包括2002年的磷脂双层纳米颗粒（21）和2017年基于银纳米线渗滤网络的高效空气过滤器（22）。这些概念在今天引起了强烈共鸣，特别是随着纳米科学和纳米技术的不断发展到COVID-19和其他解决方案。2020年，这些概念在今天引起了强烈的共鸣，特别是随着纳米科学和纳米技术继续为COVID-19和其他解决方案做出贡献。2020年，这些概念在今天引起了强烈的共鸣，特别是随着纳米科学和纳米技术继续为COVID-19和其他解决方案做出贡献。2020年，Nano Letters，我们推出了Viewpoints，（23）知名学者的观点文章，他们对未来20年的纳米科学和纳米技术可能会是什么样子产生了沉思。我强烈建议您阅读这些简短的文章，内容涉及与计算和纳米光学，（24-26）纳米安全和纳米医学，（27-29）电池和无机纳米材料，（30,31）分子纳米材料，（32-34）相关的思想DNA纳米技术[35,36]等。纳米科学20年路线图由人们制定：我们的好奇心和发现适用于社会需求和环境问题。我对纳米科学的未来以及纳米字母的作用感到乐观将继续发挥；请加入我们的这项激动人心的努力。本社论中表达的观点只是作者的观点，不一定是ACS的观点。本文引用了其他36个出版物。