Abstract

Thousands of nerve injuries occur in the world each year. Axon regeneration is a very critical process for the restoration of the injured nervous system’s function. However, the precise molecular mechanism or signaling cascades that control axon regeneration are not clearly understood, especially in mammals. Therefore, there is almost no ideal treatment method to repair the nervous system’s injury until now. Mammalian axonal regeneration requires multiple signaling pathways to coordinately regulate gene expression in soma and assembly of the cytoskeleton protein in the growth cone. A better understanding of their molecular mechanisms, such as axon regeneration regulatory signaling cascades, will be helpful in developing new treatment strategies for promoting axon regeneration. In this review, we mainly focus on describing these regeneration-associated signaling cascades, which regulate axon regeneration.

中文翻译：

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损伤后成熟神经元的内在轴突再生特性

摘要

每年世界上发生数以千计的神经损伤。轴突再生是恢复受损神经系统功能的非常关键的过程。但是，控制轴突再生的精确分子机制或信号级联尚不清楚，尤其是在哺乳动物中。因此，到目前为止，几乎没有理想的治疗方法来修复神经系统的损伤。哺乳动物的轴突再生需要多种信号通路来协调调节躯体中的基因表达和生长锥中细胞骨架蛋白的组装。更好地了解其分子机制，例如轴突再生调节信号转导级联，将有助于开发新的促进轴突再生的治疗策略。在这篇评论中