Swirling Instability of the Microtubule Cytoskeleton,Physical Review Letters

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Swirling Instability of the Microtubule Cytoskeleton
Physical Review Letters ( IF 8.1 ) Pub Date : 2021-01-13 , DOI: 10.1103/physrevlett.126.028103
David B Stein ₁ , Gabriele De Canio ₂ , Eric Lauga ₂ , Michael J Shelley _{1,

3} , Raymond E Goldstein ₂

Affiliation

In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long microtubules, as are the collective fluid flows generated by many moving motors. Studies of streaming during oocyte development in the fruit fly Drosophila melanogaster have shown a transition from a spatially disordered cytoskeleton, supporting flows with only short-ranged correlations, to an ordered state with a cell-spanning vortical flow. To test the hypothesis that this transition is driven by fluid-structure interactions, we study a discrete-filament model and a coarse-grained continuum theory for motors moving on a deformable cytoskeleton, both of which are shown to exhibit a swirling instability to spontaneous large-scale rotational motion, as observed.

中文翻译：

微管细胞骨架的旋转不稳定性

在细胞质流的细胞现象中，沿着微管网络携带货物的分子马达夹带周围的液体。单个电机产生的皮牛顿力足以使长微管变形，许多运动电机产生的集体流体流也是如此。对果蝇卵母细胞发育过程中流动的研究表明，从空间无序的细胞骨架（仅支持短程相关性的流动）转变为具有跨细胞涡流的有序状态。为了检验这种转变是由流体-结构相互作用驱动的假设，我们研究了在可变形细胞骨架上移动的电机的离散丝模型和粗粒度连续理论，这两种理论都被证明对自发大的旋转表现出旋转不稳定性。 - 观察到的尺度旋转运动。

更新日期：2021-01-13

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