Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation. However, a direct role for TSLP in CD8+ T-cell primary responses remains controversial and its role in memory CD8+ T cell responses to secondary viral infection is unknown. Here, we investigate the role of TSLP in both primary and recall responses in mice using two different viral systems. Interestingly, TSLP limited the primary CD8+ T-cell response to influenza but did not affect T cell function nor significantly alter the number of memory CD8+ T cells generated after influenza infection. However, TSLP inhibited memory CD8+ T-cell responses to secondary viral infection with influenza or acute systemic LCMV infection. These data reveal a previously unappreciated role for TSLP on recall CD8+ T-cell responses in response to viral infection, findings with potential translational implications.

中文翻译：

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胸腺基质淋巴细胞生成素限制初级和回忆 CD8+ T 细胞抗病毒反应


胸腺基质淋巴细胞生成素 (TSLP) 是一种细胞因子，直接作用于 CD4+ T 细胞和树突状细胞，促进哮喘、特应性皮炎和过敏性炎症的进展。然而，TSLP 在 CD8+ T 细胞初次反应中的直接作用仍然存在争议，并且其在记忆 CD8+ T 细胞对继发病毒感染的反应中的作用尚不清楚。在这里，我们使用两种不同的病毒系统研究了 TSLP 在小鼠初级反应和回忆反应中的作用。有趣的是，TSLP 限制了 CD8+ T 细胞对流感的初级反应，但不影响 T 细胞功能，也不会显着改变流感感染后产生的记忆 CD8+ T 细胞的数量。然而，TSLP 抑制记忆 CD8+ T 细胞对流感继发病毒感染或急性全身 LCMV 感染的反应。这些数据揭示了 TSLP 在响应病毒感染的召回 CD8+ T 细胞反应中的先前未被认识到的作用，这一发现具有潜在的转化意义。