Humulus pollen is an important cause of allergic asthma in East Asia. There have been some murine models for Humulus pollen allergy established by intraperitoneal (IP) sensitization and nasal drip stimulation, but they were not comprehensive enough. Here, we used atomized inhalation for challenge and compared the subcutaneous (SC) and IP sensitization routes to determine the optimal method to establish a model of asthma induced by Humulus pollen. Subsequently, we tried to develop a rapid subcutaneous immunotherapy (SCIT) model for Humulus allergy.

中文翻译：

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葎草花粉过敏小鼠哮喘模型的建立及皮下免疫治疗

葎草花粉是东亚过敏性哮喘的重要病因。已有一些通过腹腔内（IP）致敏和鼻滴刺激建立葎草花粉过敏的小鼠模型，但不够全面。在这里，我们使用雾化吸入进行攻击，并比较了皮下 (SC) 和 IP 致敏途径，以确定建立葎草花粉诱导的哮喘模型的最佳方法。随后，我们尝试开发一种针对葎草过敏的快速皮下免疫治疗 (SCIT) 模型。