The deoxyhexose sugar L-fucose is important for many biological processes within the human body and the associated microbiota. This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates. Fucosylated oligosaccharides facilitate the establishment of a healthy microbiota and provide protection from infection. However, there are instances where pathogens can also exploit these fucosylated structures to cause infection. Furthermore, deficiencies in host fucosylation are associated with specific disease outcomes. This review focuses on our current understanding of the impact of fucosylation within the mucosal environment of the gastrointestinal tract with a specific emphasis on the mediatory effects in host–microbe interactions.

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岩藻糖在肠道健康和疾病中的意义

脱氧己糖 L-岩藻糖对人体内的许多生物过程和相关微生物群都很重要。这种碳水化合物在宿主肠道粘膜表面、许多微生物细胞表面结构和一些膳食碳水化合物中含量丰富。岩藻糖基化寡糖有助于建立健康的微生物群并提供保护免受感染。然而，在某些情况下，病原体也可以利用这些岩藻糖基化结构引起感染。此外，宿主岩藻糖基化的缺陷与特定的疾病结果相关。本综述侧重于我们目前对胃肠道粘膜环境中岩藻糖基化影响的理解，特别强调宿主-微生物相互作用中的中介作用。