PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7. The iPSCs with a normal karyotype had the abilities to differentiate into three germ layers and expressed pluripotency markers without detectable residual plasmids. The cell line FJMUUHi001-A carrying the truncating protein PARK7 could be a useful tool to help comprehend the function of PARK7 in the iPSCs and differentiated cells from them.

PARK7突变是遗传的帕金森氏病的原因。诱导多能干细胞（iPSC）系FJMUUHi001-A是通过在来自32岁患者的外周血单核细胞中表达5种重编程因子OCT3 / 4，SOX2，c-MYC，KLF4和BCL-XL产生的PARK7中c.189dupA的纯合突变。具有正常核型的iPSC能够分化为三个胚层并表达多能性标记，而没有可检测到的残留质粒。携带截短蛋白PARK7的细胞系FJMUUHi001-A可能是有用的工具，有助于了解iPSC中的PARK7的功能以及从中分化出的细胞。