Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathology. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs.

Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA, BPA-g and nine sex steroid hormones using liquid chromatography tandem mass spectrometry (LC–MS/MS).

Sixty maternal and child pairs were analyzed. Rank correlation demonstrated a significant positive relationship between cord blood estradiol and cord blood BPA (p = 0.002) and maternal BPA levels (p = 0.02) respectively. Cord blood testosterone from male infants showed a negative Spearman’s correlation (r=-0.5, p = 0.02) with maternal BPA-g. There was no statistical difference in total testosterone levels in cord blood from male and female infants.

The findings of the current study indicate a significant relationship between some key sex steroid hormones namely testosterone, dihydrotestosterone and estradiol and fetal exposure BPA.

在早期发育期间，尤其是在子宫内接触双酚 A (BPA) 与多种病理学有关。本研究的目的是检查 BPA 及其天然代谢物 BPA-葡糖苷酸 (BPA-g) 与南非母子对中性类固醇激素水平的关系。

使用液相色谱串联质谱法 (LC-MS/MS) 分析孕晚期血清母体样本和匹配的脐带血样本中的 BPA、BPA-g 和九种性类固醇激素。

对 60 对母婴进行了分析。等级相关表明脐带血雌二醇和脐带血 BPA (p = 0.002) 和母体 BPA 水平 (p = 0.02) 之间存在显着的正相关关系。来自男婴的脐带血睾酮与母体 BPA-g 呈负 Spearman 相关性 (r=-0.5, p = 0.02)。男性和女性婴儿脐带血中的总睾酮水平没有统计学差异。

当前研究的结果表明，一些关键的性类固醇激素（即睾酮、二氢睾酮和雌二醇）与胎儿接触 BPA 之间存在显着关系。