Introduction

Individuals with Parkinson's disease (PD) are at increased risk of developing anxiety, cognitive decline, and reduced physical activity. Although anxiety is a risk factor for cognitive decline, the mechanisms underlying the relationship are unclear. The present study assessed if the relationship between cognition and anxiety symptoms is mediated by physical activity in a sample of individuals with PD followed for up to five years.

Methods

Participants (N = 487) were individuals newly diagnosed with Parkinson's disease followed by the Parkinson's Progression Marker Initiative (PPMI). Participants completed a neuropsychological battery and questionnaires of anxiety and physical activity. Structural equation models examined both the between-person and within-person effects of anxiety and cognition mediated through physical activity.

Results

Analyses revealed a significant direct effect of anxiety predicting cognitive functioning. Additionally, there was a significant indirect within-person effect; meaning that individuals who became more anxious over time, they also reported becoming less physically active, which was subsequently associated with longitudinal declines in cognitive functioning.

Discussion

Findings suggest that worsening anxiety early in the course of PD may be a risk factor for reduced participation in physical activities and subsequent cognitive decline.

中文翻译：

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体育活动是帕金森氏症焦虑和认知功能的中介

介绍

帕金森氏病（PD）的人患焦虑症，认知能力下降和体育活动减少的风险增加。尽管焦虑是认知能力下降的危险因素，但这种关系的潜在机制尚不清楚。本研究评估了长达5年的PD患者样本中的体育活动是否介导了认知与焦虑症状之间的关系。

方法

参与者（N = 487）是新诊断为帕金森氏病的患者，随后是帕金森氏病进展标记倡议（PPMI）。参加者完成了关于焦虑和身体活动的神经心理学电池和问卷。结构方程模型检查了通过体育活动介导的焦虑和认知在人与人之间的影响。

结果

分析显示焦虑预测认知功能的显着直接影响。此外，还有重大的间接人际效应。这意味着随着时间的流逝，焦虑变得更加严重的人，他们还报告说他们的运动量减少了，这随后导致了认知功能的纵向下降。

讨论区

研究结果表明，PD早期焦虑加剧可能是减少参加体育活动和随后的认知能力下降的危险因素。