The COVID-19 outbreak has had a dramatic impact on the healthcare system due to the rapid, worldwide spread of the virus, highlighting several considerations on the best management of infected patients and also potential risks and prognostic factors in patients with pre-existing chronic diseases exposed to the virus. Neurodegenerative disorders are known to be chronic, disabling diseases that imply a higher vulnerability to infections, and for this reason, it has been suggested that SARS-CoV-2 infection may have a worse course in these patients. In the present study, we report our experience with 12 patients affected by Parkinson’s disease (PD) who became infected with SARS-Cov-2 due to a COVID-19 outbreak in a care residency, and thus hospitalised in our COVID hospital. Most of the PD patients had a long disease duration and multiple comorbidities even though SARS-CoV-2 manifestations were mild, and none required intensive care. Despite lung conditions, most of our PD patients had mild symptoms: 7 patients were clinically asymptomatic (58.3%); 3 patients had fever, cough, and myalgia (25%) and 2 patients had dyspnoea (16%) that needed high-flow oxygen therapy. Few complications related to PD were seen. All patients were discharged after a mean hospitalisation period of 30 days. Mortality rate during hospitalisation was zero. Our findings suggest that SARS-CoV-2 infection does not have a poor prognosis in patients with PD. More extensive data and evaluations, however, are needed to confirm our data, and caution is warranted.

由于该病毒在全球范围内迅速传播，COVID-19 的爆发对医疗保健系统产生了巨大影响，凸显了对受感染患者最佳管理的几个考虑因素，以及患有既往慢性病的患者的潜在风险和预后因素暴露于病毒。众所周知，神经退行性疾病是一种慢性致残性疾病，意味着更容易受到感染，因此，有人认为 SARS-CoV-2 感染在这些患者中的病程可能会更严重。在本研究中，我们报告了 12 名帕金森病 (PD) 患者的经历，这些患者因护理住院期间爆发了 COVID-19 而感染了 SARS-Cov-2，并因此在我们的 COVID 医院住院。尽管 SARS-CoV-2 表现较轻，但大多数 PD 患者病程较长且有多种合并症，且无需重症监护。尽管有肺部疾病，我们的大多数 PD 患者症状较轻：7 名患者临床无症状（58.3%）； 3 名患者出现发烧、咳嗽和肌痛 (25%)，2 名患者出现呼吸困难 (16%)，需要高流量氧疗。很少见到与 PD 相关的并发症。所有患者平均住院 30 天后均出院。住院期间死亡率为零。我们的研究结果表明，SARS-CoV-2 感染对 PD 患者的预后并不不良。然而，需要更广泛的数据和评估来确认我们的数据，并且需要谨慎。