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Free radical scavenging and α-glucosidase inhibitory activity of (E)-methyl/ethyl-3-(2-hydroxyphenyl)acrylates
Indian Journal of Chemistry, Section B Pub Date : 2021-01-12
K Siva Hariprasad, G Harikrishna, A Zehra, A K Tiwari, B China Raju

(E)-Methyl/ethyl-3-(2-hydroxyphenyl)acrylates 3a-x have been prepared by the reaction of salicylaldehydes 1a-l with Wittig reagents such as methyl (triphenylphosphoranylidene)acetate 2a and ethyl (triphenylphosphoranylidene)acetate 2b in dry DCM at room temperature. All the synthesized compounds have been evaluated for free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3c and 3d display DPPH free radical scavenging activity. All the compounds have shown ABTS free radical scavenging activity except four compounds 3s-t and 3w-x. Compounds 3g, 3p and 3r display α-glucosidase inhibitory activity.

中文翻译:

(E)-甲基/乙基-3-(2-羟基苯基)丙烯酸酯的自由基清除和α-葡萄糖苷酶抑制活性

E)-甲基/乙基-3-(2-羟基苯基)丙烯酸甲酯3a-x是通过使水杨醛1a-1与Wittig试剂如(三苯基膦基亚甲基乙酸甲酯)乙酸酯2a和乙基(三苯基膦基亚乙基)乙酸酯2b在干燥中反应制备的室温下为DCM。已经评估了所有合成的化合物的自由基清除和α-葡萄糖苷酶抑制活性。化合物3c3d显示DPPH自由基清除活性。除了四种化合物3s-t3w-x之外,所有化合物均具有ABTS自由基清除活性。化合物3g3p3r显示α-葡糖苷酶抑制活性。
更新日期:2021-01-12
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