The work is aimed at the search of selective fluorescent sensors without using specific artificial receptors, antibodies, enzymes etc. With this end in view, methods based on non-covalent binding of target analytes are sought. We observed dramatic changes in the emission spectrum of a carbocyanine dye in a micellar surfactant solution (cetyltrimethylammonium bromide, CTAB) in the presence of dipyrone (metamizol, analgin): the 480 nm band intensity increases with a simultaneous decrease in intensity in near-IR region (720 nm). MALDI and NMR-¹H data show the intact molecules of dipyrone and the dye. The detection can be performed in the presence of other organic species and inorganic salts. Dipyrone testing is feasible within 5נ10^–7–5נ10^–4 M with RSDs of 3.5% by using a visualizer instead of a spectrofluorimeter.

该工作旨在寻找不使用特定人工受体、抗体、酶等的选择性荧光传感器。为此，寻求基于目标分析物的非共价结合的方法。我们观察到丁吡酮（安乃近、安乃近）存在下胶束表面活性剂溶液（十六烷基三甲基溴化铵，CTAB）中碳菁染料的发射光谱发生了巨大变化：480 nm 波段强度增加，同时近红外强度降低区域（720 纳米）。MALDI 和 NMR- ¹ H 数据显示了苯并吡喃酮和染料的完整分子。检测可以在其他有机物质和无机盐存在的情况下进行。Dipyrone 测试在 5נ10 ^–7 –5נ10 ^–4内是可行的 M 的 RSD 为 3.5%，使用可视化仪代替荧光分光计。